Results 61 to 70 of about 29,148 (239)
Advanced Science, EarlyView.Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang +19 more
wiley +1 more source
Sensors, 2011 Linewidth measurements of a distributed feedback (DFB) fibre laser are made using delayed self heterodyne interferometry (DHSI) with both Mach-Zehnder and Michelson interferometer configurations.
Simon Fleming +6 more
doaj +1 more source
Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276
Advanced Science, EarlyView.WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan +10 more
wiley +1 more source
Refractive Index Compensation in Over-Determined Interferometric Systems
Sensors, 2012 We present an interferometric technique based on a differential interferometry setup for measurement under atmospheric conditions. The key limiting factor in any interferometric dimensional measurement are fluctuations of the refractive index of air ...
Zdeněk Buchta +5 more
doaj +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery
Angewandte Chemie, EarlyView.Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer +7 more
wiley +2 more sources
Optical Fiber-Based MR-Compatible Sensors for Medical Applications: An Overview
Sensors, 2013 During last decades, Magnetic Resonance (MR)—compatible sensors based on different techniques have been developed due to growing demand for application in medicine.
Emiliano Schena +4 more
doaj +1 more source
Geomatics, Natural Hazards & Risk, 2020 The primary objective of these studies was to quantitatively assess the ground deformation velocities and rates and their natural and man-made controlling factors as the potential risks along the seismically active 70 km section of buried Baku-Tbilisi ...
Emil Bayramov +2 more
doaj +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
Sensors, 2019 This paper presents a 10 to 20 GHz bandwidth microwave polarimeter demonstrator, based on the implementation of a near-infra-red frequency up-conversion stage that allows both the optical correlation, when operating as a synthesized-image interferometer,
Francisco J. Casas +6 more
doaj +1 more source