Results 61 to 70 of about 104,312 (252)

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Single-Pass Bistatic SAR Interferometry Using Fixed-Receiver Configurations: Theory and Experimental Validation [PDF]

, 2010
In this paper, bistatic interferometry using fixed-receiver configurations is addressed both theoretically and experimentally. The analytical expressions for interferometric phase and height sensitivity are derived, and a full interferometric processing ...
Mallorqui, Jordi J., Duque, Sergi, Lopez-Dekker, Paco, Sergi Duque, Paco Lopez-Dekker, Jordi J Mallorqui   +5 more
core   +1 more source

Refractive Index Compensation in Over-Determined Interferometric Systems

Sensors, 2012
We present an interferometric technique based on a differential interferometry setup for measurement under atmospheric conditions. The key limiting factor in any interferometric dimensional measurement are fluctuations of the refractive index of air ...
Zdeněk Buchta, Jan Hrabina, Martin Čížek, Ondřej Číp, Miroslava Holá, Josef Lazar   +5 more
doaj   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Optical Fiber-Based MR-Compatible Sensors for Medical Applications: An Overview

Sensors, 2013
During last decades, Magnetic Resonance (MR)—compatible sensors based on different techniques have been developed due to growing demand for application in medicine.
Emiliano Schena, Paola Saccomandi, Domenico Formica, Fabrizio Taffoni, Giovanni Di Pino   +4 more
doaj   +1 more source

Quantitative assessment of ground deformations for the risk management of petroleum and gas pipelines using radar interferometry

Geomatics, Natural Hazards & Risk, 2020
The primary objective of these studies was to quantitatively assess the ground deformation velocities and rates and their natural and man-made controlling factors as the potential risks along the seismically active 70 km section of buried Baku-Tbilisi ...
Emil Bayramov, Manfred Buchroithner, Martin Kada   +2 more
doaj   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Acceleration computing process in wavelength scanning interferometry [PDF]

, 2011
The optical interferometry has been widely explored for surface measurement due to the advantages of non-contact and high accuracy interrogation. Eventually, some interferometers are used to measure both rough and smooth surfaces such as white light ...
Gao, F., Muhamedsalih, Hussam, Jiang, Xiang   +2 more
core   +1 more source

A Microwave Polarimeter Demonstrator for Astronomy with Near-Infra-Red Up-Conversion for Optical Correlation and Detection

Sensors, 2019
This paper presents a 10 to 20 GHz bandwidth microwave polarimeter demonstrator, based on the implementation of a near-infra-red frequency up-conversion stage that allows both the optical correlation, when operating as a synthesized-image interferometer,
Francisco J. Casas, David Ortiz, Beatriz Aja, Luisa de la Fuente, Eduardo Artal, Rubén Ruiz, Jesús M. Mirapeix   +6 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source