Results 91 to 100 of about 203,970 (332)

Synthetic Bilirubin‐Based Nanomedicine Protects Against Renal Ischemia/Reperfusion Injury Through Antioxidant and Immune‐Modulating Activity

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan, Hyunjin Kim, Bomin Kim, Honglin Piao, Joon Young Jang, Tae Kyeom Kang, Wook‐Bin Lee, Dohyeon Kim, Seunghyun Jo, Duckhyang Shin, Sharif MD Abuzar, Myung L. Kim, Jaeseok Yang, Sangyong Jon   +13 more
wiley   +1 more source

Tratamento de hemangioma gigante com interferon alfa: relato de dois casos Treatment of giant hemangioma with interferon-alpha: report of two cases

Revista Brasileira de Hematologia e Hemoterapia, 2007
O objetivo do trabalho é descrever o uso de interferon alfa no tratamento de pacientes com hemangioma gigante. Os autores relatam e analisam dois casos de hemangioma gigante em tratamento com interferon alfa. IBS, 3 anos, em acompanhamento no Ambulatório
Ana Julia Balau, Livia C. De Nadai, Mônica S. Bressan, Josiane L. Simão   +3 more
doaj   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block [PDF]

, 2017
Type I interferon (IFN) signaling engenders an antiviral state that likely plays an important role in constraining HIV-1 transmission and contributes to defining subsequent AIDS pathogenesis.
Aziz, Muhamad Afiq Bin, Busnadiego, Idoia, Foster, Toshana L., Hughes, Joseph, Neil, Stuart J.D., Rihn, Suzannah J., Wilson, Sam J.   +6 more
core   +3 more sources

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Topical Interferon Alpha 2b in the Treatment of Refractory Diabetic Macular Edema

Journal of Ophthalmic & Vision Research, 2020
Purpose: To report the efficacy of topical interferon alpha 2b in the treatment of refractory diabetic macular edema. Methods: In this retrospective interventional case series, five eyes of three individuals with diabetic macular edema resistant to
Arash Maleki, Andrew Phillips Stephenson, Fedra Hajizadeh   +2 more
doaj   +1 more source

Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans [PDF]

, 2008
BACKGROUND: Systemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain ...
Brydon, Lena, Critchley, Hugo D., Harrison, Neil A., Steptoe, Andrew, Walker, Cicely   +4 more
core   +2 more sources

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

New approaches and therapeutic modalities for the treatment of patients with chronic hepatitis C

Annals of Hepatology, 2005
A major challenge in the field of hepatology is the fight against hepatitis C that affects more than 150 million people world-wide. Despite the enormous improvement that has been achieved in the therapy of chronic hepatitis C over the last decade, there ...
Markus Cornberg, Michael P. Manns
doaj  

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection [PDF]

, 2013
Persistent production of type I interferon (IFN) by activated plasmacytoid dendritic cells (pDC) is a leading model to explain chronic immune activation in human immunodeficiency virus (HIV) infection but direct evidence for this is lacking.
A Biancotto, A Boasso, A Boasso, A Chahroudi, A Pichlmair, Amanda P. Smith, AR Sedaghat, AS Beignon, AW Hardy, B Jacquelin, B Malleret, C Guiducci, C Hirotsu, C Kornfeld, C Pasare, CA Dutertre, Cristiana Guiducci, D Favre, D Hackl, Daniel Normolle, DE Levy, DJ Shedlock, DK Monteith, DK Monteith, DL Sodora, Elizabeth R. Wonderlich, ER Wonderlich, FJ Barrat, FJ Barrat, Franck J. Barrat, G Silvestri, Guido Silvestri, I Pandrea, IV Pandrea, J Estaquier, JA Phillips, JA Tavel, JD Estes, JD Estes, JD Estes, JM Brenchley, JM Orendi, JN Mandl, JP Herbeuval, JP Herbeuval, K Honda, KD Mir, KN Brown, KN Brown, KN Brown, L Campillo-Gimenez, LD Harris, LJ Picker, M Manion, M Murphey-Corb, M Nascimbeni, M O'Brien, M Ries, M Swiecki, MP Longhi, Muhamuda Kader, N Sachsenberg, NL Letvin, P Fitzgerald-Bocarsly, PD Katsikis, R Ellegard, RK Reeves, RS Geary, RS Geary, S Feldman, S Fiorentini, S Kwa, S Lederer, SE Bosinger, SE Bosinger, Simon C. Watkins, Simon M. Barratt-Boyes, TH Vanderford, V Monceaux, V Soumelis   +79 more
core   +3 more sources