Fibrosis‐3 index (FIB‐3) can stratify the risk of the survival and the recurrence‐free survival. The FIB‐3 index is a reliable, age‐independent tool for assessing liver fibrosis and prognosis in HCC patients post‐hepatectomy. Its use may improve clinical outcomes and support personalized treatment strategies. Abstract Background Liver fibrosis is a key
Yuki Imaoka+13 more
wiley +1 more source
TGFB2 mRNA Levels Prognostically Interact with Interferon-Alpha Receptor Activation of IRF9 and IFI27, and an Immune Checkpoint LGALS9 to Impact Overall Survival in Pancreatic Ductal Adenocarcinoma. [PDF]
Qazi S, Trieu V.
europepmc +1 more source
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky+3 more
wiley +1 more source
Efficacy and safety of interferon-alpha 1b injection into the intervertebral foramen with ultrasonic guidance in patients with postherpetic neuralgia: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial. [PDF]
Hu HM+9 more
europepmc +1 more source
Hyperthyroidism in a patient with chronic hepatitis C during alpha-interferon therapy.
Yoshiko Yamazaki+4 more
openalex +2 more sources
Intralesional interferon alpha-2b as a novel treatment for periocular squamous cell carcinoma in horses. [PDF]
Martabano BB+6 more
europepmc +1 more source
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov+2 more
wiley +1 more source
Anti-Tumor Immunity to Patient-Derived Breast Cancer Cells by Vaccination with Interferon-Alpha-Conditioned Dendritic Cells (IFN-DC). [PDF]
Lapenta C+15 more
europepmc +1 more source
ABSTRACT Background Particulate matter ⩽2.5 µm in diameter (PM2.5) and its role in chronic rhinosinusitis (CRS) pathogenesis have gained heightened attention. We previously demonstrated that PM2.5 exposure may bias the nasal mucosa in CRS toward a Type 2 inflammatory pathway.
Rory J. Lubner+5 more
wiley +1 more source
C-X-C chemokine receptor type 5<sup>+</sup>CD8<sup>+</sup> T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferon-alpha treatment. [PDF]
Xu ZY, Dai ZS, Gong GZ, Zhang M.
europepmc +1 more source