Interferon alpha suppresses alphaherpesvirus immediate early protein levels in sensory neurons, leading to the establishment of a latent infection [PDF]
, 2010 Alphaherpesviruses are a subfamily of the herpesviruses containing closely related human and animal pathogens, including human herpes simplex virus (HSV-1) and porcine pseudorabies virus (PRV)
De Regge, Nick +4 more
core
Inflammatory signaling compromises cell responses to interferon alpha. [PDF]
, 2011 Interferon alpha (IFNα) is widely used for treatment of melanoma and certain other malignancies. This cytokine as well as the related IFNβ exerts potent anti-tumorigenic effects; however, their efficacy in patients is often suboptimal.
Baker, D P +7 more
core +1 more source
Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients. [PDF]
PLoS ONE, 2017 To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha ...
Marie-Quitterie Picat +10 more
doaj +1 more source
Long-term follow-up of Philadelphia chromosome-positive (Ph+) chronic myeloid leukaemia (CML) in children and adolescents managed at a single institution over a 20-year period [PDF]
, 2005 Chronic myeloid leukaemia (CML) is rare in childhood. In our Institution we managed 30 consecutive Ph+CML patients aged
DE CUIA MR +7 more
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, 2014 AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and ...
Amanzada, Ahmad +3 more
core +1 more source
Therapeutic effectiveness of interferon alpha 2b treatment for COVID-19 patient recovery [PDF]
, 2020 Rosana Pereda +9 more
openalex +1 more source
A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]
, 2019 Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y. +2 more
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Type I interferons in tuberculosis: Foe and occasionally friend [PDF]
, 2018 Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K +3 more
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A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract [PDF]
, 2016 Background: Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with ...
E. Soulis +10 more
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The rebound effect in the treatment of complex hemangioma with interferon alpha 2A
São Paulo Medical JournalThe authors report the case of an infant with an extensive face hemangioma with subglottic airway obstruction which had been successfully treated with interferon alpha 2A but then reoccurred with the same dimensions and airway blockage after treatment ...
Jaime Anger +4 more
doaj +1 more source