Results 121 to 130 of about 50,714 (355)

Response of lymphocytes to a mitogenic stimulus during spaceflight [PDF]

Several studies were performed that demonstrate that immunological activities of lymphocytes can be affected by spaceflight or by models that attempt to simulate some aspects of weightlessness.
Sonnenfeld, Gerald
core   +1 more source

Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice [PDF]

, 2012
Yanzheng Tong, Jun Cui, Qingtian Li, Jia Zou, Helen Y. Wang, Rong‐Fu Wang   +5 more
openalex   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Selected Milestones in Antiviral Drug Development

Viruses
This review article will describe the (wide) variety of approaches that I envisaged to develop a specific therapy for viral infections: (i) interferon and its inducers, (ii) HSV, VZV and CMV inhibitors, (iii) NRTIs (nucleoside reverse transcriptase ...
Erik De Clercq
doaj   +1 more source

An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms

Frontiers in Immunology, 2019
Nuclear factor kappa B (NFκB) is a transcription factor that controls inflammation and cell survival. In clinical histology, elevated NFκB activity is a hallmark of poor prognosis in inflammatory disease and cancer, and may be the result of a combination
Simon Mitchell, Ellen L. Mercado, Adewunmi Adelaja, Jessica Q. Ho, Quen J. Cheng, Gourisankar Ghosh, Alexander Hoffmann, Alexander Hoffmann   +7 more
doaj   +1 more source

Interferon-induced ISG15 pathway: an ongoing virus–host battle [PDF]

, 2013
Chen Zhao, Mark N. Collins, Tien-Ying Hsiang, Robert M. Krug   +3 more
openalex   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Evaluation of preventive effects of interferon inducer against acute respiratory viral infections in young people

Лечащий Врач, 2021
The results of observational non-interventional prospective study of application of kagocel for prevention of ARVI and influenza during epidemic rise of morbidity among young people were presented.
E. P. Tikhonova, T. Yu. Kuzmina, Yu. S. Kalinina   +2 more
doaj  

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers. [PDF]

Bioorg Med Chem Lett, 2020
Chu Y, Raja Sekhara Reddy B, Pratap Reddy Gajulapalli V, Sudhakar Babu K, Kim E, Lee S.   +5 more
europepmc   +1 more source