Results 1 to 10 of about 22,805,379 (236)

SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3 [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Corona virus disease 2019 (COVID-19) pathogenesis is intimately linked to the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) and disease severity has been associated with compromised induction of type I interferon (IFN-I) cytokines which ...
Raul S. Freitas, Tyler F. Crum, Kislay Parvatiyar   +2 more
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Avian Metapneumovirus Subgroup C Phosphoprotein Suppresses Type I Interferon Production by Blocking Interferon Regulatory Factor 3 Nuclear Translocation [PDF]

Microbiology Spectrum, 2023
Avian metapneumovirus subgroup C (aMPV/C) is an important pathogen that causes upper respiratory symptoms and egg production decline in turkeys and chickens. aMPV/C infection leads to inhibition of the host antiviral immune response.
Lei Hou, Yongyan Shi, Jinshuo Guo, Tong Sun, Dedong Wang, Xiaoyu Yang, Changzhe Liu, Yongqiu Cui, Ning Zhu, Xinxin Tong, Yang Pan, Xufei Feng, Jianwei Zhou, Jue Liu   +13 more
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Serine-arginine splicing factor 2 promotes oesophageal cancer progression by regulating alternative splicing of interferon regulatory factor 3 [PDF]

RNA Biology, 2023
Objective Often, alternative splicing is used by cancer cells to produce or increase proteins that promote growth and survival through alternative splicing.
Ziqing Wei, Yuyao Wang, Wenyuan Ma, Wenqing Xing, Peng Lu, Zhijie Shang, Feng Li, Huiyu Li, Yuxuan Wang   +8 more
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Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection [PDF]

Frontiers in Immunology, 2023
Interferon regulatory factors (IRFs) are key elements of antiviral innate responses that regulate the transcription of interferons (IFNs) and IFN-stimulated genes (ISGs).
Joseph K. Sampson Duncan, Danyang Xu, Maria Licursi, Michael A. Joyce, Michael A. Joyce, Holly A. Saffran, Holly A. Saffran, Kaiwen Liu, Jin Gohda, D. Lorne Tyrrell, D. Lorne Tyrrell, Yasushi Kawaguchi, Yasushi Kawaguchi, Yasushi Kawaguchi, Kensuke Hirasawa   +14 more
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Interferon Regulatory Factor 3 Exacerbates the Severity of COVID-19 in Mice [PDF]

Critical Care Explorations
CONTEXT:. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019, causing the COVID-19 pandemic. While most infected people experienced mild illness, others progressed to severe disease, characterized by hyperinflammation and ...
Wendy E. Walker, PhD, Luiz F. Garcia, MS, Pedro M. Palermo, PhD, Nawar Hakim, MD, Dinesh G. Goswami, PhD, Alok K. Dwivedi, PhD, Douglas M. Watts, PhD   +6 more
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EBV (LMP1) enhances cisplatin resistance by enhancing degradation of interferon regulatory factor 3 [PDF]

Cell Communication and Signaling
EBV employs multiple strategies to subvert host innate immunity, including suppression of type I IFN signaling. However, the precise mechanism by which its latent oncoprotein LMP1 modulates this pathway in nasopharyngeal carcinoma (NPC) remains unclear ...
Yueshuo Li, Na Liu, Chenxing Yang, Shan He, Cheng Luo, Lin Wang, Min Tang, Xiangjian Luo, Ya Cao, Li Shang, Feng Shi   +10 more
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Stromal Interferon Regulatory Factor 3 Can Antagonize Human Papillomavirus Replication by Supporting Epithelial-to-Mesenchymal Transition [PDF]

Viruses
Epithelia contribute to the innate immune system through barrier formation and through signaling to immune cells. When the barrier is breached, epithelial cells undergo epithelial-to-mesenchymal transition (EMT) as part of the wound healing process.
Oluwamuyiwa T. Amusan, Rebecca Lopez, Elijah Burks, Jessica Trammel, Gaurav Raikhy, Hongyan Guo, Jason Bodily   +6 more
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Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation [PDF]

Veterinary Research
Getah virus (GETV), a neglected and re-emerging mosquito-borne alphavirus, has become more serious and poses a potential threat to animal safety and public health.
Hua Liu, Zhao Qi, Lan Tian, Zhe Chen, Haonan Li, Le Liu, Sicong Liu, Shuai Li, Jiumeng Sun, Ying Shao, Xiangjun Song, Jian Tu, Liangqiang Zhu, Kezong Qi, Zhenyu Wang   +14 more
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Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3 [PDF]

Frontiers in Immunology, 2017
The influenza A virus (IAV) can be recognized by retinoic acid-inducible gene I (RIG-I) to activate the type I interferon response and induce antiviral effects.
Chenyang Yi, Chenyang Yi, Chenyang Yi, Chenyang Yi, Zongzheng Zhao, Zongzheng Zhao, Zongzheng Zhao, Zongzheng Zhao, Shengyu Wang, Shengyu Wang, Shengyu Wang, Shengyu Wang, Xin Sun, Xin Sun, Xin Sun, Xin Sun, Dan Zhang, Dan Zhang, Dan Zhang, Dan Zhang, Xiaomei Sun, Xiaomei Sun, Xiaomei Sun, Xiaomei Sun, Anding Zhang, Anding Zhang, Anding Zhang, Anding Zhang, Meilin Jin, Meilin Jin, Meilin Jin, Meilin Jin   +31 more
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Down-regulated GATA-1 up-regulates interferon regulatory factor 3 in lung adenocarcinoma [PDF]

Scientific Reports, 2017
Interferon regulatory factor 3 (IRF-3) is widely known for its prompt response against viral infection by activating the interferon system. We previously reported that E2F1, Sp1 and Sp3 regulated transcriptional activity of IRF-3.
Lu-Lu Wang, Zheng-Sen Chen, Wen-Di Zhou, Jin Shu, Xiao-Hua Wang, Rui Jin, Li-Li Zhuang, Mir Alireza Hoda, Hao Zhang, Guo-Ping Zhou   +9 more
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