Results 231 to 240 of about 87,441 (309)

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Clinical, demographic, and pharmacological predictors of medication adherence to disease-modifying therapies in multiple sclerosis: a multidimensional analysis of merged survey and claims data. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Thavarajasingam A, Fricke LM, Krauth C.
europepmc   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Type I interferons enhance B cell activation and promote differentiation of double negative 2 cells in SLE. [PDF]

Lupus Sci Med
Faheem Z, Boukhaled GM, Nassar C, Manion K, Kim M, Bonilla D, Gladman DD, Whittall Garcia L, Touma Z, Brooks DG, Wither J.   +10 more
europepmc   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Grass carp catalase inhibits GCRV replication through ROS scavenging-mediated immune suppression and autophagy. [PDF]

Virulence
Wang X, Zou X, Liu L, Liang X, Wang H, Yang C, Li Y, Liao L, Zhu Z, Wang Y, Zhao J, He L.   +11 more
europepmc   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Differential antiviral effects and immune responses in nasal and airway organoid during RSV infection: implications for interferon therapy. [PDF]

Front Immunol
Wang L, Chen L, Yang L, Hu Y, Lu D, Duan Y, Qiu L, Li Y, Zhang R, Liu H, Yang W.   +10 more
europepmc   +1 more source

Interfering with innate immunity: type I IFNs and avian influenza susceptibility. [PDF]

EBioMedicine
Tangye SG, Ma CS.
europepmc   +1 more source

Oropouche virus infects primary human intestinal organoids and is inhibited by type I and III interferon treatment. [PDF]

mBio
Wang X, Li J, Biharie A, de Vries AC, Bijvelds MJC, Janssen HLA, Wang W, Souza WMd, Pan Q.   +8 more
europepmc   +1 more source