Results 121 to 130 of about 142,617 (267)
Dermatology ReportsBackground: Hedgehog Pathway Inhibitors (HHIs) should be offered to patients with advanced BCC as a first line treatment. Two systemic HHIs are currently available: sonidegib and vismodegib.
Italian Melanoma Intergroup
doaj +1 more source
Advanced Science, EarlyView.HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng +10 more
wiley +1 more source
15 | Clinico-pathological features of superficial angiosarcomas: a retrospective study
Dermatology ReportsBackground: Angiosarcoma (AS) is a rare malignant vascular neoplasm, classified as either deep or superficial. Among superficial forms, cutaneous angiosarcoma (cAS) and radiation-induced angiosarcoma of the breast (RIAS) are the most frequent.
Italian Melanoma Intergroup
doaj +1 more source
Reducing prejudice and addressing inequalities with intergroup contact
, 2019 Recent research on intergroup contact has shown that contact, instead of promoting greater intergroup equality, may in some conditions have unintended effects on social change and collective action intentions, both among disadvantaged and advantaged ...
Vezzali, Loris +5 more
core
, 2018 Past research is limited by a focus on intimacy in positive intergroup contact. This study tested whether intergroup intimacy counteracts or amplifies the detrimental effects of negative intergroup contact on outgroup attitudes.
Paolini, Stefania +2 more
core +1 more source
Advanced Science, EarlyView.Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng +10 more
wiley +1 more source
Dermatology ReportsBackground: Sentinel lymph node biopsy (SLNB) in melanoma allows the identification of patients with clinically non-palpable metastatic lymph nodes. The risk of nodal involvement is related to Breslow thickness, ulceration, or mitotic rate.
Italian Melanoma Intergroup
doaj +1 more source
Intergroup contact moderates the influence of social norms on prejudice
, 2019 While previous research has examined social norms and intergroup contact as predictors of prejudice, there is limited research on their interplay in shaping intergroup attitudes. The results of five studies using correlational and experimental methods in
Falomir Pichastor, Juan Manuel +5 more
core +1 more source
Advanced Science, EarlyView.VCIPIP1 emerges as a molecular link between protein stability and prostate cancer progression. By deubiquitinating and stabilizing UBE3A, VCIPIP1 promotes p53 degradation and progression to castration‐resistant prostate cancer. Elevated VCIPIP1 expression is associated with shorter castration‐resistant prostate cancer–free survival, highlighting the ...
Fei Lin +9 more
wiley +1 more source
Dermatology ReportsBackground: Immunotherapy has significantly improved survival outcomes in metastatic melanoma. Following the Checkmate 067, in January 2022, the Italian Medicines Agency (AIFA) approved combination of Nivolumab+Ipilimumab for the treatment of metastatic
Italian Melanoma Intergroup
doaj +1 more source