Results 41 to 50 of about 10,897 (237)

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Comparison of Paresthesia Mapping With Anatomic Placement in Burst Spinal Cord Stimulation: Long‐Term Results of the Prospective, Multicenter, Randomized, Double‐Blind, Crossover CRISP Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Spinal cord stimulation (SCS) is an effective therapy for chronic intractable pain. Conventional SCS involves electrode placement based on intraoperative paresthesia mapping; however, newer paradigms like burst may allow for anatomic placement of leads.
Adnan Al‐Kaisy, Ganesan Baranidharan, Haggai Sharon, Stefano Palmisani, David Pang, Onita Will, Samuel Wesley, Tracey Crowther, Karl Ward, Paul Castino, Adil Raza, Yagna J. Pathak, Filippo Agnesi, Thomas Yearwood   +13 more
wiley   +1 more source

Cohesion Without Consensus: Attitudinal Profiles of Social Cohesion in Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT Headline indicators of social cohesion in Australia have remained stable in recent years despite rising political polarisation and declining institutional trust worldwide. Yet recent protests and incidents of ethnically and politically motivated violence suggest that cohesion may be under strain. If cohesion is understood not as the pursuit of
John van Kooy
wiley   +1 more source

The Effect of Online Parent Training With and Without Coaching Support on the Well‐Being of Families of Children With Neurodisabilities: A Randomized Controlled Trial

Autism Research, EarlyView.
ABSTRACT Families of children with neurodisabilities often face significant child behavioral challenges that can affect overall family functioning and well‐being. This randomized controlled trial (RCT) used family resilience theory as the investigative framework to examine the impact of an online parenting program designed to address child behavioral ...
Jeffrey McCrossin, Ali Filali‐Mouhim, Michael Ungar, Karen McEwan, Kathleen O'Grady, Donna Thomson, Parent Advisory Group, Patricia Lingley‐Pottie, Patrick McGrath, Lucyna M. Lach   +9 more
wiley   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

To know you is to love you: Effects of intergroup contact and knowledge on intergroup anxiety and prejudice among indigenous Chileans

International Journal of Psychology, 2015
Two surveys were conducted in Chile with indigenous Mapuche participants (N study 1: 573; N study 2: 198). In line with previous theorising, it was predicted that intergroup contact with the non‐indigenous majority reduces prejudice. It was expected that this effect would be because of contact leading to more knowledge about the outgroup, which would ...
Hanna, Zagefka, Roberto, González, Rupert, Brown, Siugmin, Lay, Jorge, Manzi, Nicolás, Didier   +5 more
openaire   +5 more sources

Utility and Emotion: A Combined Economic‐Psychological Approach to Understanding Consumer Preferences for Social Farming Products

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACTSocial farming integrates agricultural activities with social and rehabilitative functions, offering significant benefits to communities. However, its economic sustainability depends, among other factors, on consumer acceptance and willingness to pay a premium for its products.
Francesca Moino, Giovanbattista Califano, Francesco Basset, Patrizia Borsotto, Giovanni Dara Guccione, Francesca Giarè   +5 more
wiley   +1 more source

Рredictors of behavioral strategy choice among Russians in intercultural conflict

Социальная психология и общество, 2019
The article describes the main results of the study investigating the predictors of the behavioral strategy choice among Russians in an imaginary conflict with a representative of the North Caucasus ethnic groups. The theoretical and methodological basis
Batkhina A.A., Lebedeva N.M.
doaj   +1 more source

‘Us versus them’: A social identity perspective of internal medicine trainees

Perspectives on Medical Education, 2022
Introduction Silos and group boundaries in the clinical workplace can result in interprofessional conflict which can be a source of anxiety for doctors in training.
Joanne Kerins, Samantha Eve Smith, Victoria Ruth Tallentire   +2 more
doaj   +1 more source

‘Working Through’ Interpersonal Transgressions: The Role of Narration (and Re‐Narration) in the Self‐Forgiveness Processes of Wrongdoers

European Journal of Social Psychology, EarlyView.
ABSTRACT This research examines how wrongdoers may use narration to ‘work through’ a transgression committed, towards self‐forgiveness and reconciliation. In Study 1 (N = 30), reflexive thematic analysis was used to identify narrative types observable in wrongdoers’ storying of a recent interpersonal transgression, informing our conceptual framework ...
Christiana Harous, Michael Wenzel, Lydia Woodyatt   +2 more
wiley   +1 more source