HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Anti-suit Injunctions as Means of Avoidance of Parallel Arbitration and Court Proceedings
Наукові записки НаУКМА: Юридичні науки, 2019 Parallel proceedings in the international commercial arbitration pose a number of challenges to all parties of such proceedings. Therefore, as a means of avoiding the abovementioned problem, a mechanism of anti-suit measures was developed. Nowadays, anti-
Mariia Deviatkina
doaj +1 more source
Decoupling Accountability and Liability
Naveiñ Reet: Nordic Journal of Law and Social Research, 2020 As open public data initiatives have become prevalent among local and national governments across the globe with promises of benefits such as increased accountability, challenges, especially the governments’ lack of willingness to open public data, have
Cancan Wang, Kalina Staykova
doaj +1 more source
Are Britain’s railways costing too much? Perspectives based on TFP comparisons with British Rail: 1963-2002. [PDF]
, 2004 Following the Hatfield accident in October 2000, the cost of running Britain’s railways has increased very sharply, leading to considerable debate about whether current cost levels are reasonable.
Smith, A.S.J.
core
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Interim results: the effect of intra-articular extended-release triamcinolone acetonide on OARSI-recommended physical performance measures in adults with bilateral symptomatic knee OA [PDF]
, 2021 Neil A. Segal, Mohit Kothari
openalex +1 more source
Making the Most of Interim Assessment Data: Lessons from Philadelphia [PDF]
, 2009 Under No Child Left Behind, urban school districts have increasingly turned to interim assessments, administered at regular intervals, to help gauge student progress in advance of annual state exams.
Cecily A. Mitchell +5 more
core
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
BMC Medical Research Methodology, 2020 Background Because of unknown features of the COVID-19 and the complexity of the population affected, standard clinical trial designs on treatments may not be optimal in such patients.
Shesh N. Rai +5 more
doaj +1 more source