Advanced Science, EarlyView.Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang +6 more
wiley +1 more source
Design of Partial Mueller-Matrix Polarimeters for Application-Specific Sensors. [PDF]
Sensors (Basel)Hoover BG, Takane MY.
europepmc +1 more source
Structural Colors from Modulated Topological Defects in Molecular Smectic Liquid Crystals
Advanced Science, EarlyView.Rather than using dyes and pigments, nature produces the colors of some butterflies and beetles through optical interference phenomena. This study describes an original biomimetic strategy exploiting the spontaneous formation of modulated linear defects in thin films of 8CB, a common molecular liquid crystal.
Camille N. Mahyaoui +7 more
wiley +1 more source
Cones of Noether-Lefschetz divisors and moduli spaces of hyperkähler manifolds. [PDF]
Math AnnBarros I, Beri P, Flapan L, Williams B.
europepmc +1 more source
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Anisotropic Cellular Forces Drive Hexagonal-to-Tetragonal Tiling Transitions in the Drosophila Eye. [PDF]
Dev Growth DifferZheng T, Davis SR, Li C, Ren W, Sato M.
europepmc +1 more source
Advanced Science, EarlyView.In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang +13 more
wiley +1 more source
Liquid Atmospheric Pressure MALDI (LAP-MALDI) Mass Spectrometry: A Versatile Tool for the Characterization of Synthetic Polymers. [PDF]
Rapid Commun Mass SpectromKowalczyk AE +3 more
europepmc +1 more source
Surface and Interfacial Engineering toward Durable Mechanically Coupled Flexible Electronics
Advanced Science, EarlyView.This Review highlights how surface and interfacial engineering governs the reliability, durability, and functional stability of mechanically coupled flexible electronics. By integrating fundamental interfacial theory, failure mechanisms, multiscale engineering strategies, and representative applications, it provides a design‐oriented framework for ...
Qian Wang, Fangfang Dai, Wei Wu
wiley +1 more source
Revealing the Application of Synchrotron-Based X-Ray Computed Tomography in Healthy Versus Unhealthy Interior Lodgepole Pine (<i>Pinus contorta</i> var. <i>latifolia</i>) Conelets. [PDF]
Plant DirectDykstra E +3 more
europepmc +1 more source