Results 51 to 60 of about 17,353,800 (271)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Mathematical Modelling and Analysis, 2018 An arc search interior-point algorithm for monotone symmetric cone linear complementarity problem is presented. The algorithm estimates the central path by an ellipse and follows an ellipsoidal approximation of the central path to reach an ε-approximate ...
Mohammad Pirhaji +3 more
doaj +1 more source
Volumetric Barrier Cutting Plane Algorithms for Stochastic Linear Semi-Infinite Optimization
IEEE Access, 2020 In this paper, we study the two-stage stochastic linear semi-infinite programming with recourse to handle uncertainty in data defining (deterministic) linear semi-infinite programming.
Baha Alzalg, Asma Gafour, Lewa Alzaleq
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
An interior proximal gradient method for nonconvex optimization
Open Journal of Mathematical OptimizationWe consider structured minimization problems subject to smooth inequality constraints and present a flexible algorithm that combines interior point (IP) and proximal gradient schemes.
De Marchi, Alberto, Themelis, Andreas
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Interior-point methods in parallel computation [PDF]
30th Annual Symposium on Foundations of Computer Science, 1989 Interior-point methods for linear programming, developed in the context of sequential computation, are used to obtain a parallel algorithm for the bipartite matching problem. The algorithm runs in O*( square root m) time. The results extend to the weighted bipartite matching problem and to the zero-one minimum-cost flow problem, yielding O*( square ...
Andrew V. Goldberg +3 more
openaire +2 more sources
Communications in Combinatorics and Optimization, 2018 An infeasible interior-point algorithm for solving the $P_*$-matrix linear complementarity problem based on a kernel function with trigonometric barrier term is analyzed.
B. Kheirfam, M. Haghighi
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source