Results 61 to 70 of about 94,026 (261)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Вестник Дагестанского государственного технического университета: Технические науки, 2018 . Objectives An analysis of open access literature sources and normative documents on the problem of information protection in automated systems was carried out.
Irina G. Drovnikova +3 more
doaj +1 more source
Hot dense silica glass with ultrahigh elastic moduli
Scientific Reports, 2022 Silicate and oxide glasses are often chemically doped with a variety of cations to tune for desirable properties in technological applications, but their performances are often limited by relatively lower mechanical and elastic properties.
Ningyu Sun +4 more
doaj +1 more source
Seismic anisotropy beneath the Chinese Mainland: Constraints from shear wave splitting analyses
Earthquake Research Advances, 2021 We use earthquakes recorded by the China National Seismic Network from 2015 to 2019 and measure shear wave splitting parameters of SKS to study the anisotropic characteristics beneath the mainland of China.
Lingxia Gao, Daoyuan Sun
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Seismological evidence for a localized mushy zone at the Earth’s inner core boundary
Nature Communications, 2017 The existence of a mushy zone in the Earth’s inner core has been suggested, but has remained unproven. Here, the authors have discovered a 4–8 km thick mushy zone at the inner core boundary beneath the Okhotsk Sea, indicating that there may be more ...
Dongdong Tian, Lianxing Wen
doaj +1 more source
The Geometric Interior in Real Linear Spaces [PDF]
Formalized Mathematics, 2010 The Geometric Interior in Real Linear Spaces We introduce the notions of the geometric interior and the centre of mass for subsets of real linear spaces. We prove a number of theorems concerning these notions which are used in the theory of abstract simplicial complexes.
openaire +2 more sources
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source