Results 71 to 80 of about 5,729,077 (300)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of Interior Space Design and Visual Artistic Effect

open access: yes, 2018
Interior space is the basic living environment structure of human beings, and it is the material environment for people to live and work. Therefore, the design of interior space involves the relationship between people and space, and often reflects the ...
Wang Qian
semanticscholar   +1 more source

METHODOLOGY FOR INVESTIGATING THE PROBABILITY-TIME CHARACTERISTICS OF NETWORK ATTACKS IN THE SIMULATION MODELLING SOFTWARE ENVIRONMENT

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2018
. Objectives An analysis of open access literature sources and normative documents on the problem of information protection in automated systems was carried out.
Irina G. Drovnikova   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The Mode of Trench-Parallel Subduction of the Middle Ocean Ridge

open access: yesFrontiers in Earth Science, 2021
Trench-parallel subduction of mid-ocean ridges occurs frequently in plate motion history, such as along the western boundary of the Pacific plate in the early Cenozoic and along the eastern boundary of the Pacific plate at present.
Xiaobing Shen, Wei Leng, Wei Leng
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The Geometric Interior in Real Linear Spaces [PDF]

open access: yesFormalized Mathematics, 2010
The Geometric Interior in Real Linear Spaces We introduce the notions of the geometric interior and the centre of mass for subsets of real linear spaces. We prove a number of theorems concerning these notions which are used in the theory of abstract simplicial complexes.
openaire   +2 more sources

Filling an Urban Void as a ‘Public Interior’ in Balikesir; Contemporary Intervention into Historic Context through Interior Space

open access: yes, 2017
The paper argues the role of interior spaces in linking with the urban open space configuration. The interior space is discussed as extensions of urban spaces and urban spaces as extensions of interiors with specific reference to a case study selected in
M. Çetin
semanticscholar   +1 more source

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