Results 1 to 10 of about 4,660 (169)

Development of Nodular Lesions after Dupilumab Therapy in Erythrodermic Mycosis Fungoides with Interleukin-13 Receptor alpha2 Expression. [PDF]

Acta Derm Venereol, 2022
is missing (Short communication)
Hashimoto M, Miyagaki T, Komaki R, Takeuchi S, Kadono T.   +4 more
europepmc   +2 more sources

A Novel Role of Interleukin 13 Receptor alpha2 in Perineural Invasion and its Association with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma

Cancers, 2020
Perineural invasion (PNI) is one of the major pathological characteristics of pancreatic ductal adeno-carcinoma (PDAC), which is mediated by invading cancer cells into nerve cells. Herein, we identify the overexpression of Interleukin-13 Receptor alpha2 (
T. Fujisawa, T. Shimamura, Kaku Goto, R. Nakagawa, R. Muroyama, Y. Ino, H. Horiuchi, I. Endo, S. Maeda, Y. Harihara, A. Nakajima, N. Matsuhashi, N. Kato, H. Isayama, Ankit Puri, A. Suzuki, Ian H. Bellayr, P. Leland, B. Joshi, R. Puri   +19 more
semanticscholar   +1 more source

Interleukin-13 Receptor Subunit Alpha-2

Definitions, 2020
Interleukin-13 receptor subunit alpha-2 (380 aa, ~44 kDa) is encoded by the human IL13RA2 gene. This protein plays a role in both B-cell differentiation and maturation.

semanticscholar   +1 more source

Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†

Biology of Reproduction, 2020
The endometrium, composed of epithelial and stromal cell compartments, is tightly regulated by the ovarian steroid hormones estrogen (E2) and progesterone (P4) during early pregnancy. Through the progesterone receptor (PGR), steroid receptor coactivators,
R. Marquardt, Kevin Y. Lee, Tae Hoon Kim, Brandon Lee, F. DeMayo, Jae-Wook Jeong   +5 more
semanticscholar   +1 more source

Analysis of interleukin-13 receptor alpha2 expression as a prognostic biomarker in surgically resected pancreatic cancer patients

Journal of Immunotherapy for Cancer, 2015
Meeting abstracts IL-13Rα2 is recognized as one of the candidate genes significantly associated with pancreatic cancer risk. Previously, we have demonstrated that IL-13Rα2 is over-expressed in ~70% of human pancreatic cancer samples.
T. Fujisawa, T. Shimamura, B. Joshi, R. Puri   +3 more
semanticscholar   +1 more source

Generation of interleukin-13 receptor alpha2 antigen expressing modified vaccinia ankara recombinant virus for potential cancer immunotherapy

Journal of Immunotherapy for Cancer, 2014
Genetically modified recombinant poxviruses have shown promise in preclinical models of cancer immunotherapy due to their ability to induce effective cell-mediated immunity against target tumor-associated antigens (TAA).
Y. Sato, Ramjay S. Vatsan, B. Joshi, S. R. Husain, R. Puri   +4 more
semanticscholar   +1 more source

Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

Nature Communications, 2017
The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is undetectable in normal brain which makes it a highly suitable target for diagnostic and therapeutic ...
J. Newman, G. Wang, K. Arima, S. P. Guan, M. Waters, W. Cavenee, E. Pan, E. Aliwarga, S. Chong, Catherine Y L Kok, B. Endaya, A. Habib, T. Horibe, W. Ng, I. Ho, K. Hui, T. Kordula, P. Lam   +17 more
semanticscholar   +2 more sources

The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor (*)

Journal of Biological Chemistry, 1995
Interleukin (IL)-13 elicits a subset of the biological activities of the related IL-4. The basis of this functional similarity is that their specific cell-surface receptors (called IL-13R and IL-4R) are distinct, yet are complex and share a common ...
S. Zurawski, P. Chomarat, O. Djossou, Christine Bidaud, A. McKenzie, P. Miossec, J. Banchereau, G. Zurawski   +7 more
semanticscholar   +1 more source

Analysis of the cancer genome atlas (TCGA) database identifies an inverse relationship between interleukin-13 receptor α1 and α2 gene expression and poor prognosis and drug resistance in subjects with glioblastoma multiforme

Journal of Neuro-Oncology, 2017
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. A variety of targeted agents are being tested in the clinic including cancer vaccines, immunotoxins, antibodies and T cell immunotherapy for GBM.
Jing Han, R. Puri
semanticscholar   +1 more source

Specifically targeted killing of interleukin-13 (IL-13) receptor-expressing breast cancer by IL-13 fusion cytotoxin in animal model of human disease.

Molecular Cancer Therapeutics, 2004
Interleukin-13 receptor (IL-13R) alpha2 chain binds IL-13 with high affinity and can internalize after binding to ligand. We have exploited this property of IL-13Ralpha2 chain by receptor-targeted breast cancer therapy. Previous studies have demonstrated
K. Kawakami, M. Kawakami, R. Puri
semanticscholar   +1 more source