Results 11 to 20 of about 3,824 (132)

Harnessing chimeric antigen receptor macrophages against solid tumors. [PDF]

Cancer Commun (Lond)
Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Wang M, Qin Z, Bian XW, Shi Y.
europepmc   +2 more sources

Development of a nutritional screening and assessment indicator system for patients with esophageal cancer in China: Findings from the Delphi method

Cancer Medicine, Volume 12, Issue 23, Page 21240-21255, December 2023., 2023
Abstract Background In China, individuals diagnosed with esophageal cancer are confronted with an elevated risk of nutritional inadequacy or malnutrition throughout the course of their disease, a condition that contributes to various adverse clinical outcomes.
Jingjing Shang, Wen Dong, Peipei Huang, Yidan Sun, Yuxin He, Hui Li, Shengwu Liao, Mei Li   +7 more
wiley   +1 more source

Equine allergic skin diseases: Clinical consensus guidelines of the World Association for Veterinary Dermatology

Veterinary Dermatology, Volume 34, Issue 3, Page 175-208, June 2023., 2023
Abstract Background Allergic skin diseases are common in horses worldwide. The most common causes are insect bites and environmental allergens. Objectives To review the current literature and provide consensus on pathogenesis, diagnosis, treatment and prevention. Materials and Methods The authors reviewed the literature up to November 2022.
R. Marsella, S. White, V. A. Fadok, D. Wilson, R. Mueller, C. Outerbridge, W. Rosenkrantz   +6 more
wiley   +1 more source

Dissecting the role of toll‐like receptor 7 in pancreatic cancer

Cancer Medicine, Volume 12, Issue 7, Page 8542-8556, April 2023., 2023
There are conflicting reports regarding the expression pattern and function of TLR7 in pancreatic cancer. A new study shows that high TLR7 expression correlates with shorter overall survival and its inhibition results in reduced cell viability. Abstract Background Toll‐like receptors (TLRs) are gaining attention for their potential to influence tumor ...
Maren Stark, Marina Nicolai, Marina Tatura, Corinna U. Keber, Andreas Kaufmann, Ho‐Ryun Chung, Emily P. Slater, Christopher Heeschen, Rita T. Lawlor, Aldo Scarpa, Detlef K. Bartsch, Thomas M. Gress, Stefan Bauer, Malte Buchholz   +13 more
wiley   +1 more source

Dynamic regulation of the transcriptome and proteome of the equine embryo during maternal recognition of pregnancy

FASEB BioAdvances, Volume 4, Issue 12, Page 775-797, December 2022., 2022
Abstract During initial maternal recognition of pregnancy (MRP), the equine embryo displays a series of unique events characterized by rapid blastocyst expansion, secretion of a diverse array of molecules, and transuterine migration to interact with the uterine surface.
Alba Rudolf Vegas, Giorgia Podico, Igor F. Canisso, Heinrich Bollwein, Thomas Fröhlich, Stefan Bauersachs, Carmen Almiñana   +6 more
wiley   +1 more source

Short-chain acyl post-translational modifications in cancers: Mechanisms, roles, and therapeutic implications. [PDF]

Cancer Commun (Lond)
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Wu T, Zhao Y, Zhang X, Wang Y, Chen Q, Zhang M, Sheng H, Zhang Y, Guo J, Li J, Fan Y, Wang Z, Li Y, Wang H, Wei M, Hu X, Wu H.   +16 more
europepmc   +2 more sources

Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma [PDF]

, 2007
Background In patients with high grade glioma, little is known regarding existence of naturally occurring adaptive T cell reactivity against glioma-associated antigens (GAAs).
Ryo Ueda, Keri L Low, Xinmei Zhu, Mitsugu Fujita, Kotaro Sasaki, Theresa L Whiteside, Lisa H Butterfield, Hideho Okada   +7 more
core   +1 more source

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers [PDF]

, 2017
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Andrews, Bazan, Bazan, Bendall, Borden, Constantinescu, Delgoffe, Donohue, Fujiwara, Gil, Grant, Greenwell-Wild, Heller, Hoshino, Huising, Ihle, Jahn, Juntilla, Kasahara, Kawahara, Krutzik, Laporte, Lemmon, Levin, Levin, Levy, Marijanovic, Mitra, Moraga, Moraga, Moraga, Murray, Ng, O'Shea, Ohashi, Pattyn, Rafei, Saeed, Schaeffer, Sharif, Songyang, Spangler, Stroud, Thomas, Ullrich, Umemiya-Okada, van Boxel-Dezaire, Vercelli, Vignais, Wang, Wang, Wells, Wenzel, Zhu   +53 more
core   +2 more sources

Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]

, 2017
Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J, Hockman, Tyler M, Wiese, Ashley J, Yaksh, Tony L   +3 more
core   +2 more sources

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies. [PDF]

, 2015
Alpha-2-macroglobulin is an abundant secreted protein that is of particular interest because of its diverse ligand binding profile and multifunctional nature, which includes roles as a protease inhibitor and as a molecular chaperone.
A Hawe, A Marrero, A Panyutich, AJ Barrett, AJ Barrett, AJ Barrett, Amy R. Wyatt, AR Wyatt, AR Wyatt, BF Erlanger, C Fabrizi, Christopher M. Dobson, CM Petersen, D Lauer, D Ozawa, DK Strickland, DR Thal, E Gabellieri, E Gabellieri, ED Flory, F Van Leuven, F Van Leuven, FU Hartl, G Birkenmeier, G Birkenmeier, GR Hilton, GS Salvesen, GS Salvesen, J Herz, J LaMarre, Janet R. Kumita, JC Bonner, JC Lee, JF Carpenter, JJ Abbink, JJ Yerbury, JM Mettenburg, K French, KA Pikal-Cleland, KP Crookston, KP Crookston, L Sottrup-Jensen, LJ Larsson, M Gunnarsson, M Narita, M Sunderic, Mark R. Wilson, MC Manning, MJ Imber, N Boisset, Natalie E. Farrawell, PA Dennis, PK Donnelly, PK Smith, RE Banks, Reza Khodarahmi, SD Allison, SG Roman, SK Moestrup, SM Wu, SM Wu, SR Feldman, SR Hughes, SV Lale, T Arakawa, T Kurecki, V Adler, V Ignjatovic, VY Reddy, VY Reddy, W Borth, W Hollander, Y Du   +72 more
core   +4 more sources