Results 21 to 30 of about 4,660 (169)

Mapping determinants of cytokine signaling via protein engineering [PDF]

, 2018
Cytokines comprise a large family of secreted ligands that are critical for the regulation of immune homeostasis. Cytokines initiate signaling via dimerization or oligomerization of the cognate receptor subunits, triggering the activation of the Janus ...
Alcami, Andrews, Andrews, Atanasova, Avalos, Ballinger, Becker, Boulanger, Boyman, Boyman, Boyman, Boyman, Brooks, Brown, Bulut, Charych, Chatterjee, Chill, Chomarat, Claudinon, Constantinescu, Constantinescu, Constantinescu, Cwirla, de, Elliott, Foster, Francois-Newton, Fujiwara, Gandhi, Gauzzi, Gent, German, Go, Haan, Heim, Heller, Ho, Ihle, Irandoust, Jaitin, Jaks, Jones, Junttila, Junttila, Kalie, Kalie, Kawahara, Keeler, Kelly-Welch, Kim, Klapper, Kovanen, Krause, Kurgonaite, LaPorte, Leonard, Levin, Levin, Levy, Li, Liang, Liao, Liu, Livnah, Lutz, MacNeil, Malka, Margolin, Marijanovic, Matthews, Mendoza, Mitra, Moore, Moraga, Moraga, Moraga, Moraga, Moraga, Mosser, Murray, Ohashi, Pattyn, Payelle-Brogard, Pellegrini, Pestka, Pestka, Piehler, Pillet, Porritt, Ramana, Rao, Rao, Rao, Reddy, Redpath, Remy, Richter, Rochman, Roisman, Romo, Ross, Rui, Schaeffer, Schindler, Schreiber, Schreiber, Shah, Shanafelt, Shanafelt, Smith, Smith, Spangler, Staerk, Steel, Subramaniam, Tenhumberg, Thomas, Urin, Vieira, Waldmann, Walter, Wang, Waters, Wills-Karp, Wilmes, Yamaoka, Yoon, You, Zhang, Zhang, Zhu   +131 more
core   +3 more sources

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation [PDF]

, 2016
yesInflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance.
Alomar, Anna D. White, Bain, Benoit Viollet, Benziane, Bess, Bijland, Boyle, Brenner, Castanares-Zapatero, Chen, Claire Rutherford, Cohen, Coughlan, Delyth Graham, Dong, Erik A. Richter, Ewart, Flannery, Foretz, Fritzen, Galic, García-García, Gauthier, Green, Guigas, Göransson, Habinowski, Hawley, Ian P. Salt, Jeong, Jørgensen, Kim, Kim, Kwon, Laderoute, Lee, Lihn, Lihn, Lumeng, Meares, Miyokawa-Gorin, Moreno, Mottillo, Nerstedt, Qu, Rhian M. Touyz, Rios, Ross, Rotter, Rutherford, Sag, Salt, Sarah J. Mancini, Scott, Shibata, Silvia Bijland, Sun, Takahashi, Thiefes, Timothy M. Palmer, Viollet, Wang, Wang, Wang, Woods, Wu, Xu, Yang, Zaha, Zhang, Zhao   +71 more
core   +5 more sources

Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABAA and mGlu receptor subtypes [PDF]

, 2011
RATIONALE: Repeated activation of corticotropin-releasing factor (CRF) receptors is associated with increased anxiety and enhanced stress responsivity, which may be mediated via limbic GABAergic and glutamatergic transmission.
Berend Olivier, Christiaan H. Vinkers, Hendrikus Hendriksen, James M. Cook, Lucianne Groenink, Mark J. Millan, Ruud van Oorschot, Shengming Huang, Sundari Rallipalli   +8 more
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The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]

, 2010
The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami, Al-Riyammi, Aoyama, Baev, Bashir, Bogoyevitch, Borghouts, Bowdish, Bowdish, Bradley, Brattig, Burke, Burke, Burke, Busse, Calpe, Choubey, Clutter, Cooper, Couper, Croese, Dagia, Deehan, Diaz, Dittrich, Divangahi, Elliott, Elliott, Elliott, Everts, Fabriek, Falcone, Fulkerson, Goodridge, Goodridge, Goodridge, Goodridge, Goodridge, Gu, Hamerman, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, He, Houston, Hunter, Ishibashi, Jayapal, Johnson, Kakinuma, Katschke, Kean, Khan, Kim, King, Kitagaki, Kuroki, Lai, Lai, Lamb, Lubberts, Maizels, Mansoor, Marshall, Maurer, McInnes, McInnes, Melendez, Mendoza, Mi, Mori, Moriyama, Moriyama, Moriyama, Nagel-Wolfrum, Node, Page, Polfliet, Pushparaj, Pushparaj, Rajan, Reddy, Rioja, Rogers, Satoh, Saunders, Schnoeller, Schramm, Schramm, Steinfelder, Strickland, Subramanian, Suciu-Foca, Thalhamer, Thomas, Tilstra, van Riet, Wang, Wang, WHO, Wills-Karp, Wilson, Wohlleben, Wong, Wray, Zaccone   +111 more
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Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Easton, A. J. (Andrew J.), Lord, Mike, Roberts, L. M. (Lynne M.), Smith, Daniel C., Spooner, Robert A.   +4 more
core   +2 more sources

Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence [PDF]

, 2013
Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind.
Blednov, Yuri A., Gorini, Giorgio, Harris, R. Adon, Mayfield, R. Dayne, Nunez, Yury O., Ponomareva, Olga N., Truitt, Jay M.   +6 more
core   +2 more sources

Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review [PDF]

, 2009
Background Granulocyte-colony stimulating factor (G-CSF) shows promise as a treatment for stroke. This systematic review assesses G-CSF in experimental ischaemic stroke.
Alvarez-Dolado, Bath, Bath, Claire L. Gibson, Crain, Crossley, del Zoppo, Egger, England, Fisher, Gibson, Gibson, Gibson, Han, Hasselblatt, Hermann, Jendelova, Kawada, Kollmar, Komine-Kobayashi, Lan, Lee, Lees, Macleod, Matchett, Minnerup, Nagata, Philip M.W. Bath, Schabitz, Schneider, Schneider, Sehara, Sehara, Sena, Sevimli, Shuaib, Shyu, Shyu, Shyu, Six, Solaroglu, Solaroglu, Sprigg, Sprigg, Sykova, Taguchi, Timothy J. England, Toth, Vellenga, Wardlaw, Willmot, Yanqing, Zhao, Zhao, Zsebo, Zucali   +55 more
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Impact of Gene Modifiers on Cystic Fibrosis Phenotypic Profiles: A Systematic Review. [PDF]

Hum Mutat
Cystic fibrosis (CF) is a complex monogenic disorder with a large variability in disease severity. Growing evidence suggests that the variation observed depends not only on variations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene but also on modifier genes.
Ward A, Mauleon R, Ooi CY, Rosic N.
europepmc   +2 more sources

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers [PDF]

, 2017
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Andrews, Bazan, Bazan, Bendall, Borden, Constantinescu, Delgoffe, Donohue, Fujiwara, Gil, Grant, Greenwell-Wild, Heller, Hoshino, Huising, Ihle, Jahn, Juntilla, Kasahara, Kawahara, Krutzik, Laporte, Lemmon, Levin, Levin, Levy, Marijanovic, Mitra, Moraga, Moraga, Moraga, Murray, Ng, O'Shea, Ohashi, Pattyn, Rafei, Saeed, Schaeffer, Sharif, Songyang, Spangler, Stroud, Thomas, Ullrich, Umemiya-Okada, van Boxel-Dezaire, Vercelli, Vignais, Wang, Wang, Wells, Wenzel, Zhu   +53 more
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Etiology and Pharmacology of Neuropathic Pain [PDF]

, 2018
Injury to or disease of the nervous system can invoke chronic and sometimes intractable neuropathic pain. Many parallel, interdependent, and time-dependent processes, including neuroimmune interactions at the peripheral, supraspinal, and spinal levels ...
Alles, SRA, Smith, PA
core   +1 more source