Results 31 to 40 of about 4,660 (169)

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies. [PDF]

open access: yes, 2015
Alpha-2-macroglobulin is an abundant secreted protein that is of particular interest because of its diverse ligand binding profile and multifunctional nature, which includes roles as a protease inhibitor and as a molecular chaperone.
A Hawe   +72 more
core   +4 more sources

Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation [PDF]

open access: yes, 2013
AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy balance. AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while ...
Ahmadian   +182 more
core   +1 more source

Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis [PDF]

open access: yes, 2014
Infantile hemangiomas (IHs) are non-malignant, largely cutaneous vascular tumors affecting approximately 5–10% of children to varying degrees. During the first year of life, these tumors are strongly proliferative, reaching an average size ranging from 2
AMAYA, CLARISSA   +10 more
core   +1 more source

Current evidence for a modulation of low back pain by human genetic variants [PDF]

open access: yes, 2009
The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle   +200 more
core   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

open access: yesVeterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis   +9 more
wiley   +1 more source

Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]

open access: yes, 2017
Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J   +3 more
core   +2 more sources

High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion [PDF]

open access: yes, 2018
Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity.
Alganga, Husam   +9 more
core   +2 more sources

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3 [PDF]

open access: yes, 2004
INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
Bell, A.K.   +9 more
core  

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. [PDF]

open access: yes, 2017
Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species.
Brenner, David A   +11 more
core   +1 more source

RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis [PDF]

open access: yes, 2012
BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction.
Daniel P Heruth   +4 more
core   +1 more source

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