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Interleukin 2: Biology and biochemistry
Journal of Clinical Immunology, 1983Since its discovery as a T-cell growth factor, interleukin 2 (IL-2) has attracted considerable scientific attention, not only as a useful reagent for the maintenance of large numbers of effector T lymphocytes but as a potentially potent immunoregulatory molecule, which could be of therapeutic usefulness in a number of clinical conditions.
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1985
Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Kathleen F. Bongiovanni +6 more
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Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Kathleen F. Bongiovanni +6 more
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The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
Nature reviews. Immunology, 2015D. Klatzmann, A. Abbas
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A function for interleukin 2 in Foxp3-expressing regulatory T cells
Nature Immunology, 2005J. Fontenot +3 more
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The phylogeny of interleukin-2
Developmental & Comparative Immunology, 1985Nicholas Cohen, David Watkins
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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
Cell, 1993B. Sadlack +5 more
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