Results 311 to 320 of about 3,093,388 (334)

Interleukin-21 and Cancer Therapy

2009
Interleukin-21 (IL-21) is a pleiotropic cytokine structurally similar to IL-2 and IL-15 but with important distinctions in its biological properties. IL-21 is mainly secreted by activated CD4+ T cells, NKT cells, and follicular T helper (Tfh) cells. The IL-21 receptor is expressed physiologically on lymphoid tissues and peripheral blood mononuclear ...
Davis, Ian D., Skak, Kresten, Hunder, Naomi, Smyth, Mark J., Sivakumar, Pallavur V.   +4 more
openaire   +3 more sources

Targeting interleukin-21 in rheumatoid arthritis

Molecular Biology Reports, 2010
Interleukin-21 (IL-21) is a new member of the type I cytokine superfamily, which binds to a composite receptor that consists of a private receptor (IL-21R) and the common cytokine receptor γ chain. Recently, increasing evidence has shown that IL-21 contributes to the pathogenesis of chronic inflammatory and autoimmune diseases because of its pro ...
Feng-Lai Yuan, Rui-Sheng Xu, Fei-Hu Chen, Cheng Jin, Cheng-Wan Li, Wei Hu, Jian-Ping Li, Wei-Guo Lu, Xia Li   +8 more
openaire   +3 more sources

MiR302c, Sp1, and NFATc2 regulate interleukin‐21 expression in human CD4+CD45RO+ T lymphocytes

Journal of Cellular Physiology, 2018
Interleukin‐21 (IL‐21) is a cytokine with potent regulatory effects on different immune cells. Recently, IL‐21 has been contemplated for use in the treatment of cancers. However, the molecular mechanisms regulating human IL‐21 gene expression has not yet
Hassan El-Said, M. Fayyad-kazan, R. Aoun, Nada Borghol, Najwa Skafi, R. Rouas, L. Vanhamme, Mohamad Mourtada, M. Ezzeddine, A. Burny, H. Fayyad-kazan, B. Badran   +11 more
semanticscholar   +1 more source

The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus

Gene, 2014
Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases, with complex genetic components. Interleukin-21 (IL-21) is the most recently discovered member of the type-I cytokine family, which has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production.
Yan Lan, Bin Luo, Jun-Li Wang, Yuan-Wen Jiang, Ye-Sheng Wei   +4 more
openaire   +3 more sources

Targeting Interleukin-21 in Immune-Mediated Pathologies

Current Drug Targets, 2010
Interleukin (IL)-21, a cytokine mostly produced by activated CD4+ T cells, has been reported to play an important role in the tissue-damaging immune response in various organs. This pathogenic effect is strictly linked to the ability of IL-21 to control the functional activities of multiple immune and non-immune cells. For instance, IL-21 regulates the
Sarra, M, PALLONE, FRANCESCO, Macdonald, TT, MONTELEONE, GIOVANNI   +3 more
openaire   +4 more sources

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Nature Medicine, 2009
T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice.
Caruso, R, Botti, E, Sarra, M, Esposito, M, Stolfi, C, Diluvio, L, Giustizieri, ML, Pacciani, V, Mazzotta, A, Campione, E, MacDonald, TT, CHIMENTI, SERGIO, PALLONE, FRANCESCO, COSTANZO, ANTONIO, MONTELEONE, GIOVANNI   +14 more
openaire   +3 more sources

Saliva, Serum Levels of Interleukin-21, -33 and Prostaglandin E2 in Patients with Generalised Aggressive or Chronic Periodontitis.

Oral Health & Preventive Dentistry, 2017
PURPOSE This cross-sectional study aims to evaluate saliva, serum levels of interleukin-21 (IL-21), IL-33, and prostaglandin E2 (PGE2) in patients with generalised chronic periodontitis or aggressive periodontitis.
P. Gümüş, N. Nizam, A. Nalbantsoy, Özgün Özçaka, N. Buduneli   +4 more
semanticscholar   +1 more source

Evidence of Interleukin 21 Reduction in Osteosarcoma Patients Due to PD-1/PD-L1-Mediated Suppression of Follicular Helper T Cell Functionality.

DNA and Cell Biology, 2017
Interleukin 21 (IL-21) is crucial for the development of a robust CD8+ T cell response and has been shown to promote antitumor immunity. Despite the fact that osteosarcoma presents significant genetic instability with a high immunogenic potential, the ...
Wenwu Gao, Jun-jie Zhou, Bin Ji
semanticscholar   +1 more source

Interleukin 21: combination strategies for cancer therapy

Nature Reviews Drug Discovery, 2008
In the past 20 years researchers have attempted to activate the host immune defence system to kill tumour cells and eradicate cancer. In some cases, the response of patients to immunotherapy has been extremely successful; however, other trials have shown disappointing results, and so there is a clear need for more effective therapies that can ...
Skak, Kresten, Kragh, Michael, Hausman, Diana, Smyth, Mark J., Sivakumar, Pallavur V.   +4 more
openaire   +4 more sources

Interleukin-21: biology and application to cancer therapy

Expert Opinion on Biological Therapy, 2008
IL-21, a recently described common gamma-chain cytokine, can induce the maturation and enhanced cytotoxicity of natural killer (NK) and CD8(+) T cells and proliferation of CD40-stimulated B cells. Exogenous IL-21 has antitumor effects in murine models via immunological mechanisms.
John M. Timmerman, David J Andorsky
openaire   +3 more sources