Results 1 to 10 of about 1,240,457 (275)

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. [PDF]

Proceedings of the National Academy of Sciences, 1985
We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression had markedly declined. The IL-2-induced increase in IL-2
J. Depper, W. Leonard, C. Drogula, M. Krönke, T. Waldmann, W. Greene   +5 more
semanticscholar   +4 more sources

The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2 (IL-2) [PDF]

Journal of Clinical Immunology, 1986
Approximately 65% (11/17) of cancer patients participating in an ongoing Phase I clinical trial with recombinant interleukin-2 developed nonneutralizing serum IgG anti-interleukin-2 antibodies within 1 month of initiating therapy. These antibodies could be detected using any of several standard techniques including immunoblots and enzyme-linked ...
Mark Allegretta, Michael B. Atkins, Roy A. Dempsey, Edward C. Bradley, Michael Konrad, Ann Childs, Sidney Wolfe, James W. Mier   +7 more
openalex   +4 more sources

Clearance rates and systemic effects of intravenously administered interleukin 2 (IL-2) containing preparations in human subjects. [PDF]

British Journal of Cancer, 1983
The present study was designed to examine the feasibility of in vivo administration of interleukin 2 (IL-2) to induce cytotoxic cell activity against tumours in human subjects.
C. Bindon, M. Czerniecki, P. Ruell, A. Edwards, W. McCarthy, R. Harris, P. Hersey   +6 more
semanticscholar   +2 more sources

Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor. [PDF]

Blood, 1992
DAB486IL-2 is a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with human interleukin-2 (IL-2). It selectively binds and intoxicates only cells that bear the high-affinity receptor for IL-2.
C. Lemaistre, C. Meneghetti, M. Rosenblum, J. Reuben, K. Parker, J. Shaw, A. Deisseroth, T. Woodworth, D. Parkinson   +8 more
semanticscholar   +2 more sources

Interleukin-2 (IL-2) Interacts With IL-2 Receptor Beta (IL-2Rβ): Its Potential to Enhance the Proliferation of CD4+ T Lymphocytes in Flounder (Paralichthys olivaceus) [PDF]

Frontiers in Immunology, 2020
Interleukin-2 (IL-2) is an important immunomodulatory cytokine that primarily promotes the activation, proliferation, and differentiation of CD4+ T helper subsets and CD4+ T regulatory cells.
Xiujuan Zhou, Jing Xing, Jing Xing, Xiaoqian Tang, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +2 more sources

Interleukin 2 (IL 2) administered in vivo: influence of IL 2 route and timing on T cell growth. [PDF]

Journal of Immunology, 1985
The influence of the route and the frequency of IL 2 administration on the ability of IL 2 to induce the growth of activated T cells in vivo was evaluated. Initial pharmacokinetic studies confirmed that i.v. injection of IL 2 results in a relatively high
M. Cheever, John A. Thompson, D. Kern, Philip D. Greenberg   +3 more
semanticscholar   +2 more sources

Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells. [PDF]

Journal of Clinical Investigation, 1988
A novel IL-2 receptor, distinct from the Tac protein, has been identified on the surface of purified human natural killer (NK) cells by chemical cross-linking of 125I-IL-2.
J. Kehrl, M. Dukovich, G. Whalen, P. Katz, A. Fauci, W. Greene   +5 more
semanticscholar   +2 more sources

Copper deficiency reduces interleukin-2 (IL-2) production and IL-2 mRNA in human T-lymphocytes. [PDF]

The Journal of Nutrition, 1997
Although dietary copper (Cu) deficiency has been associated with decreased production of interleukin-2 (IL-2) by activated splenic mononuclear cells in rodent models, the basis for this relationship and its relevance for humans remain unknown. To address
Robin G. Hopkins, M. L. Failla
semanticscholar   +4 more sources

Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly

Noise and Health
Context: Presbycusis can be mediated by the effects of inflammatory processes on the auditory system, and these aging biological mechanisms remain poorly studied.
Fernanda P. Cordeiro, Luciana L.M. Marchiori, Denilson C. Teixeira, Rodrigo A.C. Andraus, Regina Célia Poli-Frederico   +4 more
doaj   +2 more sources

Prophylactic and Therapeutic Effects of Interleukin-2 (IL-2)/Anti-IL-2 Complexes in Systemic Lupus Erythematosus-Like Chronic Graft-Versus-Host Disease [PDF]

Frontiers in Immunology, 2018
Murine chronic graft-versus-host-disease (cGvHD) induced by injection of parental lymphocytes into F1 hybrids results in a disease similar to systemic lupus erythematosus.
Stefan Heiler, Jonas Lötscher, Matthias Kreuzaler, Johanna Rolink, Antonius Rolink   +4 more
doaj   +2 more sources