Results 1 to 10 of about 1,332,598 (226)

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. [PDF]

Proceedings of the National Academy of Sciences, 1985
We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression had markedly declined. The IL-2-induced increase in IL-2 receptor number is maximal within 12 hr, requires new RNA and protein synthesis, and is mediated by
J M, Depper, W J, Leonard, C, Drogula, M, Krönke, T A, Waldmann, W C, Greene   +5 more
openaire   +3 more sources

Interleukin-2 (IL-2) Interacts With IL-2 Receptor Beta (IL-2Rβ): Its Potential to Enhance the Proliferation of CD4+ T Lymphocytes in Flounder (Paralichthys olivaceus) [PDF]

Frontiers in Immunology, 2020
Interleukin-2 (IL-2) is an important immunomodulatory cytokine that primarily promotes the activation, proliferation, and differentiation of CD4+ T helper subsets and CD4+ T regulatory cells.
Xiujuan Zhou, Jing Xing, Jing Xing, Xiaoqian Tang, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +2 more sources

Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly

Noise and Health
Context: Presbycusis can be mediated by the effects of inflammatory processes on the auditory system, and these aging biological mechanisms remain poorly studied.
Fernanda P. Cordeiro, Luciana L.M. Marchiori, Denilson C. Teixeira, Rodrigo A.C. Andraus, Regina Célia Poli-Frederico   +4 more
doaj   +2 more sources

Prophylactic and Therapeutic Effects of Interleukin-2 (IL-2)/Anti-IL-2 Complexes in Systemic Lupus Erythematosus-Like Chronic Graft-Versus-Host Disease [PDF]

Frontiers in Immunology, 2018
Murine chronic graft-versus-host-disease (cGvHD) induced by injection of parental lymphocytes into F1 hybrids results in a disease similar to systemic lupus erythematosus.
Stefan Heiler, Jonas Lötscher, Matthias Kreuzaler, Johanna Rolink, Antonius Rolink   +4 more
doaj   +2 more sources

Copper Deficiency Reduces Interleukin-2 (IL-2) Production and IL-2 mRNA in Human T-Lymphocytes , , [PDF]

The Journal of Nutrition, 1997
Although dietary copper (Cu) deficiency has been associated with decreased production of interleukin-2 (IL-2) by activated splenic mononuclear cells in rodent models, the basis for this relationship and its relevance for humans remain unknown. To address these matters, we have developed an in vitro model of cellular copper deficiency by treating Jurkat,
R G, Hopkins, M L, Failla
openaire   +3 more sources

Relationship Between Cysteine, Interleukin (Il)-2, and Interleukin (Il)-10 in Children with Marasmus Type Malnutrition [PDF]

Journal of Tropical Life Science, 2016
Malnutrition is one of the health issues in developing countries. The most commonly found malnutrition is the marasmus type. Infection in marasmus patient is the main cause of morbidity and mortality in developing countries.
Teguh Wahyudi, Anik Puryatni, Tinny Endang Hernowati   +2 more
doaj   +3 more sources

Data on interleukin (IL)-2- and IL-15-dependent changes in IL-2Rβ and IL-2Rγ complexes [PDF]

Data in Brief, 2017
We provide detailed datasets from our analysis of the proteins that associate with IL-2Rβ and IL-2Rγ in T-cells stimulated with IL-2 or IL-15 compared with resting T-cells, as identified by SILAC-based quantitative proteomics.
Nerea Osinalde, Virginia Sánchez-Quiles, Blagoy Blagoev, Irina Kratchmarova   +3 more
doaj   +7 more sources

RECOMBINANT CYTOKINES IN THE TREATMENT OF PNEUMONIA. CLINICAL EXPERIENCE

Interdisciplinary Approaches to Medicine, 2021
Antimicrobial chemotherapy is a keystone of the treatment of pneumonia. Prescription of antibacterial drugs does not always ensure the success of treatment due to the secondary immune deficiency developing in the process of the disease and the rapid ...
O.A. Gizinger, V.N. Egorova, V.I. Trofimov   +2 more
doaj   +3 more sources

The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation

Frontiers in Immunology, 2021
Invariant NKT (iNKT) cells are thymus-generated innate-like T cells, comprised of three distinct subsets with divergent effector functions. The molecular mechanism that drives the lineage trifurcation of immature iNKT cells into the NKT1, NKT2, and NKT17
Hee Yeun Won, Hye Kyung Kim, Assiatu Crossman, Parirokh Awasthi, Ronald E. Gress, Jung-Hyun Park   +5 more
doaj   +1 more source

Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation

Frontiers in Immunology, 2022
Cytokines are crucial molecules for maintaining the proper functioning of the immune system. Nevertheless, a dysregulation of cytokine expression could be involved in the pathogenesis of autoimmune diseases.
Dihia Meghnem, Dihia Meghnem, Mike Maillasson, Mike Maillasson, Mike Maillasson, Isabelle Barbieux, Isabelle Barbieux, Sébastien Morisseau, Sébastien Morisseau, Sébastien Morisseau, Dalloba Keita, Dalloba Keita, Yannick Jacques, Yannick Jacques, Agnès Quéméner, Agnès Quéméner, Erwan Mortier, Erwan Mortier, Erwan Mortier   +18 more
doaj   +1 more source