Results 251 to 260 of about 1,240,457 (275)

The role of interleukin-2 (IL-2) in the differentiatin of cytotoxic T cells: the effect of monoclonal anti-IL-2 antibody and absorption with IL-2 dependent T cell lines.

Journal of Immunology, 1981
A variety of approaches, including the use of a monoclonal antibody, have indicated that the lymphokine Interleukin 2 is a necessary and sufficient mediator for initiating cytotoxic T cell differentiation in vitro.
D. Kern, S. Gillis, M. Okada, C. Henney
semanticscholar   +1 more source

Immunological Mechanisms of Interleukin-2 (IL-2) Treatment in HIV/AIDS Disease

Current Molecular Pharmacology, 2009
HIV establishes a chronic infection that is marked by the progressive depletion of CD4+ T-cells, yet the mechanisms by which this depletion arises are a matter of controversy. Evidence is accumulating that T CD4+ depletion is not effected solely by virus-mediated killing and that mechanisms involving T-cell dynamics play a major role in the ...
C. Tincati, A. d'Arminio Monforte, G. Marchetti   +2 more
openaire   +4 more sources

Interleukin 2 (IL-2) activity during tumor growth: IL-2 production kinetics, absorption of and responses to exogenous IL-2

Cellular Immunology, 1984
A temporal study assessed the relationship between fibrosarcoma growth and immunologic encumbrance due to the inability of BALB/c mouse splenocytes to elaborate the lymphokine Interleukin 2 (IL-2). Nylon-wool fractionation and antiserum treatments suggested the existence of a mildly nylon-wool-adherent, anti-Lyt 2-sensitive tumor-induced suppressor T ...
Burger, C J, Elgert, K D, Farrar, W L
openaire   +3 more sources

The role of interleukin 2 (IL-2) and serum-soluble IL-2 receptor cells in idiopathic IgA nephropathy

Clinical Immunology and Immunopathology, 1992
Interleukin 2 (IL-2) plays a central role in the immune response and may be involved in the derangement of cellular immunoregulation of idiopathic IgA nephropathy (IgAN). The aim of this study was to investigate the serum levels and production of IL-2 from peripheral blood mononuclear cells (PBMC) and the distribution of IL-2 receptor cells and serum ...
F. Rivera, A. Campos, M. Parera, J. Egido   +3 more
openaire   +2 more sources

Antibodies to Interleukin-2 (IL-2) in Patients: Cross Reactivity with Different IL-2 Species

1990
Nautral interleukin-2 (nIL-2) is a polypeptide which is synthesized and secreted in a nonglycosylated as well as in two glycosylated species. The lymphokine regulates growth and differentiation of lymphocytes. It is produced by T lymphocytes upon antigenic or mitogenic stimulation.
J. Atzpodien, U. Pohl, J. Knüver-Hopf, H. Mohr, H. Kirchner   +4 more
openaire   +2 more sources

Kinetic Analysis of Interleukin 2 (IL‐2) Production and Expression of IL‐2 Receptors by Uraemic and Normal Lymphocytes

Scandinavian Journal of Immunology, 1987
The in vitro immune response of lymphocytes from uraemic patients was studied by comparing the in vitro kinetics of interleukin 2 (IL‐2) production, the mitogen‐induced proliferative response, and the expression of IL‐2 receptors by T lymphocytes. The IL‐2 production in 26 uraemic cell cultures decreased significantly after 48 h of stimulation with ...
Langhoff, E, Hofmann, B, Ødum, Niels, Ladefoged, J, Platz, P, Ryder, L P, Svejgaard, A   +6 more
openaire   +3 more sources

A microcomputer program for probit analysis of interleukin-2 (IL-2) titration data

Journal of Immunological Methods, 1986
IL-2 activity is commonly estimated in cell culture supernatants by an IL-2-dependent cell proliferation assay. This method is both reproducible and sensitive. However, it often appears from the literature that statistical analysis of the titration data either is disregarded or, when performed, is based on statistically incorrect assumptions.
Ettore Marubini, Luciano Adorini, Gino Doria, Alessandro Sette   +3 more
openaire   +3 more sources

β-Endorphin enhances interleukin-2 (IL-2) production in murine lymphocytes

Journal of Neuroimmunology, 1988
Beta-endorphin has been reported to enhance T lymphocyte proliferation and cytolytic activity. In this report, it is demonstrated that beta-endorphin enhances the production of the T cell lymphokine, interleukin-2, from mitogen-stimulated, unfractionated murine splenocytes, as well from a cloned T cell line. The enhancement is naloxone irreversible and
Leslie P. Weiner, Wendy Gilmore
openaire   +3 more sources

Interleukin 2 (IL-2) therapy: potential advantages of locoregional versus systemic administration

Cancer Treatment Reviews, 1999
There has been an apparent discrepancy between the results obtained with IL-2 based immunotherapy in animal tumour models, including veterinary cancer patients, and human cancer patients. We argue that this is due to differences in the therapeutic regimens used to treat human and veterinary cancer patients. The main differences are systemic therapy and
Bernsen, M.R., Tang, J.W., Everse, L.A., Koten, J.W., Otter, W.D.   +4 more
openaire   +3 more sources

On the role of interleukin-2 (IL-2) in multiple sclerosis (MS). IL-2-mediated endothelial cell activation.

Italian journal of neurological sciences, 1992
Increased serum levels of IL-2 and sIL-2R can be demonstrated in patients with active MS, a finding that strongly supports the hypothesis of a systemic T cell activation in such patients. However, IL-2 may play a crucial role in MS immunopathology by activating endothelial cells, as suggested by the vascular leak syndrome complicating hrIL-2 therapy ...
Gallo P, Pagni S, Piccinno M G, Giometto B, Argentiero V, Chiusole M, Bozza F, Tavolato B   +7 more
openaire   +3 more sources