Results 21 to 30 of about 1,240,457 (275)

Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75. [PDF]

The Journal of experimental medicine, 1990
We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the high affinity IL-2R, correlates with the IL-2-induced ...
Masataka Nakamura, Toshikazu Takeshita, Kazuo Sugamura, Kinya Nagata, Hironobu Asao   +4 more
openaire   +3 more sources

Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia [PDF]

Brazilian Journal of Medical and Biological Research, 2016
We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia.
W. Eik Filho, S.S. Marcon, T. Krupek, I.T.S. Previdelli, O.C.N. Pereira, M.A.R.C.P. Silva, R.B. Bazotte   +6 more
doaj   +3 more sources

Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity

Journal of Biomedical Science, 2022
Background For centuries, microbial-based agents have been investigated as a therapeutic modality for the treatment of cancer. In theory, these methods would be cheap to produce, broadly applicable in a wide array of cancer types, and could synergize ...
Yu-Jui Kung, Brandon Lam, Ssu-Hsueh Tseng, Alana MacDonald, Hsin-Fang Tu, Suyang Wang, John Lin, Ya Chea Tsai, T. C. Wu, Chien-Fu Hung   +9 more
doaj   +1 more source

Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies

Molecular Cancer, 2023
Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leading to the development of IL-2/IL-2R-targeted ...
Shan Muhammad, Tao Fan, Yang Hai, Yibo Gao, Jie He   +4 more
doaj   +1 more source

Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA).

Iraqi Journal of Pharmaceutical Sciences, 2017
Recurrent Spontaneous Abortion (RSA) is the most painful experience for couples expecting a child. This study aimed to determine the relevance of IL-2 and IL-6 in recurrent spontaneous abortion (RSA).  Serum samples were collected from 90 women attend Al
Dhamraa w. Ahmed
doaj   +3 more sources

Lipoteichoic Acid Inhibits Interleukin-2 (IL-2) Function by Direct Binding to IL-2 [PDF]

Clinical Diagnostic Laboratory Immunology, 2001
ABSTRACTLipoteichoic acid (LTA) is associated with the cell envelope of most gram-positive bacteria. Although previously thought to act mainly as a virulence factor by virtue of its adhesive nature, evidence is now provided that LTA can also suppress the function of interleukin-2 (IL-2), an autocrine growth factor for T cells.
Edmund J. Gosselin, Robert A. Jordan, Jeffrey A. Banas, Dawn M. Jelley-Gibbs, Lisa M. Plitnick, Mary C. Walsh, Mark T. Preissler   +6 more
openaire   +3 more sources

Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy

Frontiers in Cell and Developmental Biology, 2020
The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules.
Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Isaac Narbona-Sánchez, Francisco García-Cózar, Francisco García-Cózar, Arkadiusz Miazek, Enrique Aguado, Enrique Aguado   +7 more
doaj   +1 more source

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy [PDF]

, 2017
The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and ...
Fremont, Daved H, Ghasemi, Reza, Hein, Sarah M, Krupnick, Alexander Sasha, Lazear, Eric, Watkins, Dan, Westwick, John   +6 more
core   +2 more sources

[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice

Frontiers in Immunology, 2022
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule, which supports contact between leukocytes and inflamed endothelium.
Riikka Viitanen, Helena Virtanen, Heidi Liljenbäck, Heidi Liljenbäck, Olli Moisio, Xiang-Guo Li, Xiang-Guo Li, Xiang-Guo Li, Valeria Nicolini, Marine Richard, Christian Klein, Tapan Nayak, Sirpa Jalkanen, Sirpa Jalkanen, Anne Roivainen, Anne Roivainen, Anne Roivainen, Anne Roivainen   +17 more
doaj   +1 more source

IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis [PDF]

, 2019
An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE).
Burmester, Gerd-Rüdiger, Enghard, Philipp, Humrich, Jens, Kloke, Lutz, Kühl, Anja, Riemekasten, Gabriela, Rose, Angelika, von Spee-Mayer, Caroline, Wu, Kaiyin   +8 more
core   +2 more sources