Results 31 to 40 of about 1,240,457 (275)

Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes.

Blood, 1996
The physiological role of the multidrug resistance P-glycoprotein (P-gp), which is expressed by normal human T lymphocytes, is still largely unknown.
J. Drach, A. Gsur, G. Hamilton, Shourong Zhao, J. Angerler, Michael Fiegl, N. Zojer, M. Raderer, I. Haberl, M. Andreeff, H. Huber   +10 more
semanticscholar   +1 more source

The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2 [PDF]

, 1990
The gene encoding interleukin-2 (IL-2) contains a sequence 52 to 326 nucleotides upstream of its transcriptional initiation site that promotes transcription in T cells that have been activated by costimulation with tetradecanoyl phorbol myristyl acetate (
Baltimore, David, Corcoran, Lynn, Kamps, Mark P., LeBowitz, Jonathan H.   +3 more
core   +2 more sources

Study of dose-dependent combination immunotherapy using engineered T cells and IL-2 in cervical cancer [PDF]

, 2020
Adoptive T cell based immunotherapy is gaining significant traction in cancer treatment. Despite its limited success, so far, in treating solid cancers, it is increasingly successful, demonstrating to have a broader therapeutic potential. In this paper we develop a mathematical model to study the efficacy of engineered T cell receptor (TCR) T cell ...
arxiv   +1 more source

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4+ T cells potentiates type 2 immunity and promotes parasitic helminth expulsion [PDF]

, 2014
Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma.
Alexandros Englezakis, Andrew N.J. McKenzie, Barlow, Barnden, Bartemes, Chan, Chang, Christopher J. Oliphant, Cosgrove, Cote-Sierra, Emily Hams, Everts, Fallon, Fallon, Forbes, Gough, Graham S. Ogg, Halim, Halim, Hammad, Hepworth, Hoyler, Hu-Li, James M. Brewer, Jenkins, Jennifer A. Walker, Jillian L. Barlow, Jun, Kamata, Kopf, Liang, Maryam Salimi, Mirchandani, Mjösberg, Monticelli, Moro, Neill, Ohnmacht, Padraic G. Fallon, Pape, Perrigoue, Phythian-Adams, Price, Roncarolo, Salimi, Santambrogio, Schlenner, Seder, See Heng Wong, Serafini, Seth T. Scanlon, Sokol, Taieb, Turner, van Panhuys, Voehringer, Wetzel, Wong, Yamane, Yoshimoto, You Yi Hwang, Zhu   +61 more
core   +1 more source

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

Journal of Immunology, 1983
In the accompanying paper, we showed that natural killer (NK) cells were a major population in the naive spleens of normal mice that responded directly to a T cell growth factor, interleukin 2 (IL 2), and clonally replicated without other stimulating ...
K. Handa, R. Suzuki, H. Matsui, Y. Shimizu, K. Kumagai   +4 more
semanticscholar   +1 more source

Research on the Immunoregulatory Effect of Jujube Polysaccharide on Lymphocyte in Mice

Liang you shipin ke-ji, 2021
To study the immunomodulatory effect of jujube polysaccharide on mouse lymphocytes. Mouse lymphocytes were sterile separated， cell suspension was prepared， and the blank group， the positive group(levamisole) and the jujube polysaccharide group with ...
LI Feng-jiao, LI Jing-shuang, WANG Yi-lun, JIN Xin, LI Xian, YU Yang   +5 more
doaj   +1 more source

Interleukin-2 receptor antagonists for pediatric liver transplant recipients: A systematic review and meta-analysis of controlled studies [PDF]

Pediatric Transplantation, 18(8):839-850, 2014, 2014
Interleukin-2 receptor antagonists (IL-2RA) are frequently used as induction therapy in liver transplant recipients to decrease the risk of acute rejection while allowing the reduction of concomitant immunosuppression. The exact association with the use of IL-2RA however is uncertain.
arxiv   +1 more source

Interleukin-2 and the IL-2 Receptor: New Insight Into Structure and Function

Journal of Investigative Dermatology, 1990
Interleukin-2 (IL-2) was originally identified in 1976 as a growth factor for T lymphocytes. Since that time it has become an important mediator of immune function through its effects on the growth, development, and activity of T and B lymphocytes, natural killer cells, and lymphokine-activated killer cells. Only cells that bear a specific receptor for
William A Kuziel, Warner C. Greene
openaire   +3 more sources

The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosoma cruzi infection causes Chagas’ disease in humans. The infection activates the innate and adaptative immunity in an orchestrated immune response to control parasite growth, guaranteeing host survival.
Jorge Nihei, Jorge Nihei, Fabiola Cardillo, Jose Mengel, Jose Mengel   +4 more
doaj   +1 more source

Production of Interleukin-2 IL-2 and Expression of IL-2 Receptor in Patients with IgA Nephropathy

The Korean Journal of Internal Medicine, 1992
IL-2 production has been measured in several disease including type I diabetes mellitus, systemic lupus erythematosus, acquired immunodeficiency syndrome and active pulmonary sarcoidosis and its pathogenetic role was suggested. In IgA nephropathy, altered T cell subsets were reported to be associated with increased synthesis of IgA.
Myung Jae Kim, Tae Won Lee
openaire   +3 more sources