Results 31 to 40 of about 1,334,419 (369)
IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling [PDF]
, 2007 Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague ...
Bergner, Albrecht +5 more
core +1 more source
Journal of Immunology, 1983 The proliferative response of murine natural killer (NK) cells to a T cell growth factor, interleukin 2 (IL 2) was investigated by using the NK-enriched, low-density fractions (F.1) and NK-depleted, T cell-enriched, and high-density fractions (F.3) of ...
R. Suzuki, K. Handa, K. Itoh, K. Kumagai
semanticscholar +1 more source
Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]
, 1994 Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core +2 more sources
Research on the Immunoregulatory Effect of Jujube Polysaccharide on Lymphocyte in Mice
Liang you shipin ke-ji, 2021 To study the immunomodulatory effect of jujube polysaccharide on mouse lymphocytes. Mouse lymphocytes were sterile separated， cell suspension was prepared， and the blank group， the positive group(levamisole) and the jujube polysaccharide group with ...
LI Feng-jiao +5 more
doaj +1 more source
Journal of Experimental Medicine, 1991 In previous studies we demonstrated that, following activation by mitogens or alloantigens, helper T cell precursors proliferate and differentiate in vitro to produce a population of effector cells that secrete high titers of lymphokines upon ...
Linda M. Bradley +3 more
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Trypanosoma cruzi infection causes Chagas’ disease in humans. The infection activates the innate and adaptative immunity in an orchestrated immune response to control parasite growth, guaranteeing host survival.
Jorge Nihei +4 more
doaj +1 more source
Journal of Biological Chemistry, 1996 Cannabinoid receptors negatively regulate adenylate cyclase through a pertussis toxin-sensitive GTP-binding protein. In the present studies, signaling via the adenylate cyclase/cAMP pathway was investigated in the murine thymoma-derived T-cell line, EL4 ...
R. Condie +4 more
semanticscholar +1 more source
Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]
, 2019 Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix +5 more
core +1 more source
Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2) [PDF]
, 2017 Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of con-firmed HF cases in the United States. However, there are no highly effective evidence-basedtreatments currently available for these patients.
Abbate, Antonio +10 more
core +1 more source
Journal of Biological Chemistry, 1996 Proliferation of T lymphocytes is triggered by the interaction of interleukin 2 (IL-2) with its high affinity specific receptor that is expressed on the cell surface following T lymphocyte activation.
I. Flores +4 more
semanticscholar +1 more source