Results 81 to 90 of about 1,240,457 (275)

The 2nd International standard for Interleukin-2 (IL-2) Report of a collaborative study

Journal of Immunological Methods, 2013
Two candidate preparations of human sequence recombinant Interleukin-2 (IL-2) were formulated and lyophilized at NIBSC prior to evaluation in a collaborative study for their suitability to serve as a replacement international standard. The preparations were tested by eight laboratories using in vitro bioassays and immunoassays.
Robin Thorpe, Chris Bird, Paula Dilger, Alan B Heath, Meenu Wadhwa   +4 more
openaire   +3 more sources

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells [PDF]

, 1990
In this report, we explore the nature of the inductive stimuli leading to expression of the divergently regulated lymphokines interleukin 2 (IL-2) and interleukin 4 (IL-4).
Novak, Thomas J., Rothenberg, Ellen V.
core   +1 more source

Developmental and Anatomical Patterns Of IL-2 Gene Expression in Vivo in The Murine Thymus [PDF]

, 1993
Interleukin-2 (IL-2) is a potent growth factor that mature T lymphocytes synthesize and use as a proliferation signal. Much controversy has arisen concerning whether it is used to drive the extensive proliferation of immature pre-T cells in the thymus ...
Rothenberg, Ellen V., Yang-Snyder, Julia A.   +1 more
core   +3 more sources

In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system [PDF]

, 2006
We have used the tetracycline (tet)-regulated system as described previously to evaluate the applicability of controlled gene expression in cancer gene therapy. As a model gene, we used the human interleukin-2 (IL-2) gene, which has been placed under the
Pitzer, Claudia, Pomer, Sigmund, Schindowski, Katharina, Wirth, Thomas, Zöller, Margot   +4 more
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Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.

Journal of Clinical Investigation, 1993
IL-2 gene transcription is affected by several nuclear proteins. We asked whether dexamethasone (Dex) and cyclosporin A (CsA) inhibit IL-2 gene transcription by interfering with the activity of nuclear proteins that bind to the IL-2 promoter.
F. Paliogianni, Anastasios Raptis, Seema S. Ahuja, Sonia M. Najjar, Dimitrios T. Boumpas   +4 more
semanticscholar   +1 more source

A systematic review of interleukin-2-based immunotherapies in clinical trials for cancer and autoimmune diseasesResearch in context

EBioMedicine, 2023
Summary: Background: The cytokine interleukin-2 (IL-2) can stimulate both effector immune cells and regulatory T (Treg) cells. The ability of selectively engaging either of these effects has spurred interest in using IL-2 for immunotherapy of cancer and
Miro E. Raeber, Dilara Sahin, Ufuk Karakus, Onur Boyman   +3 more
doaj  

Serum Inflammatory Factor Profiles in the Pathogenesis of High-Altitude Polycythemia and Mechanisms of Acclimation to High Altitudes

Mediators of Inflammation, 2021
High-altitude polycythemia (HAPC) is a common aspect of chronic mountain sickness (CMS) caused by hypoxia and is the main cause of other symptoms associated with CMS. However, its pathogenesis and the mechanisms of high-altitude acclimation have not been
Hai Yi, Qianjin Yu, Dongfeng Zeng, Zhaohua Shen, Jiali Li, Lidan Zhu, Xi Zhang, Quanhong Xu, Hu Song, Peiyan Kong   +9 more
doaj   +1 more source

Interleukin-2 gene promoter polymorphism (T330G) and lymphocyte platelet adhesion in influenza A (H3N2)

Журнал инфектологии, 2022
Introduction. Polymorphism of cytokine genes is a factor of susceptibility or resistance to infection, the development of the disease and a long, complicated course of influenza.Objectives.
G. A. Chuprova, A. N. Emel’yanova, A. S. Emel’yanov, Yu. A. Vitkovskii   +3 more
doaj   +1 more source

1006 IMMUNE RECONSTITUTION IN PRIMARY IMMUNODEFICIENCIES BY INTERLEUKIN-2 (IL-2) [PDF]

Pediatric Research, 1985
IL-2 has been shown to have immunorestorative capabilities in some animal and human systems of acquired immunodeficiency. In this report, we present our investigations into the efficacy of recombinant IL-2 in vitro in patients with primary immunodeficiency.
William T. Shearer, A Mazumder, I.C. Guerra, Howard M. Rosenblatt   +3 more
openaire   +1 more source

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. [PDF]

, 1992
Activation of an immune response requires intercellular contact between T lymphocytes and antigen-presenting cells (APC). Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal ...
Fraser, JD, Newton, ME, Weiss, A
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