Results 331 to 340 of about 9,333,661 (382)

Structural and Functional Adaptations to Exercise Training: Paradoxical Roles of Interleukin-6 and Tumor Necrosis Factor. [PDF]

JACC Basic Transl Sci
Hogwood AC, Angadi SS, Garshick M, Abbate A.   +3 more
europepmc   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

Direct Interleukin-6 Inhibition Blunts Arterial Thrombosis by Reducing Collagen-Mediated Platelet Activation. [PDF]

Arterioscler Thromb Vasc Biol
Ministrini S, Liberale L, Puspitasari YM, Han J, Kirmes K, Unkelbach LP, Tirandi A, Niederberger R, Bengs S, Beer JH, Montecucco F, Libby P, Lüscher TF, Bongiovanni D, Camici GG.   +14 more
europepmc   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Effects of Aerobic-Resistance Training and Nutritional Intervention on Adiponectin, Interleukin-6, and hs-CRP Concentrations in Men with Abdominal Obesity-A Randomized Controlled Trial. [PDF]

Int J Mol Sci
Makiel K, Targosz A, Kosowski P, Suder A.   +3 more
europepmc   +1 more source

Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage

Advanced Science, EarlyView.
Src reduces neutrophil extracellular traps (NETs) generation and resolves acute organ damage. Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF1/MEK/ERK pathway by mediating PKC phosphorylation.
Guotao Lu, Fei Han, Yaodong Wang, Chenchen Yuan, Qingtian Zhu, Tianqi Xia, Lin Chen, Xiaowu Dong, Yanbing Ding, Weiming Xiao, Yuyan Zhang, Jiajia Pan, Hongwei Xu, Weiwei Chen, Bo Tu, Wei Li, Fei Wang, Weijuan Gong, Lianghao Hu   +18 more
wiley   +1 more source

Prognostic Utility of Prothrombin Time-International Normalized Ratio, Interleukin-6, and High-Density Lipoprotein Levels in Patients With Severe Sepsis. [PDF]

Cureus
Kurmana MK, Kumhar M, Tiwari RK, Tak H, Gaur R.   +4 more
europepmc   +1 more source

Interleukin-6 as a Predictive Marker for Lymph Node and Distant Metastasis in Colorectal Cancer: A Retrospective Cohort Study. [PDF]

Cancer Manag Res
Xiao J, Tian M, Chen G, Li H.
europepmc   +1 more source

Interleukin-6 modulates endoplasmic reticulum stress signaling and mitochondrial protein complexes in the kidney following acute exhaustive exercise. [PDF]

Cell Stress Chaperones
da Silva ASR, da Luz CM, Marafon BB, Tavares MEA, Neto IVS, Gomes Carolino RO, da Silva Ferreira DC, Marinho JT, Teixeira GR, Cintra DE, Pauli JR, Ropelle ER, de Freitas EC, Pinto AP.   +13 more
europepmc   +1 more source

Comparison of Serum Interleukin 6, Leptin, and Adiponectin Levels after Cesarean Section Under General Versus Spinal Anesthesia. [PDF]

Anesth Pain Med
Kareem Oleiwi Atabi T, Jabbari A, Ebrahimzadeh P, Bader Gazal H, Ghorbani Gholiabad S, Movafegh A.   +5 more
europepmc   +1 more source