Results 381 to 390 of about 23,313,489 (418)
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Annual Review of Immunology, 2008
Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early paradigm in which IL-2 is central for protective immune responses. This change in thinking occurred when a T regulatory cell defect was shown to be responsible for the lethal autoimmunity associated with IL-2/IL-2R deficiency. This
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Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early paradigm in which IL-2 is central for protective immune responses. This change in thinking occurred when a T regulatory cell defect was shown to be responsible for the lethal autoimmunity associated with IL-2/IL-2R deficiency. This
openaire +2 more sources
Interleukin-2, anti-interleukin-2 receptor antibody, and activation of macrophages
Cellular Immunology, 1990Macrophages treated with IFN-gamma and IL-2 before exposure to parasites develop the ability to resist infection with amastigotes of Leishmania major. In this cooperative interaction of cytokines, IL-2 can be replaced with any of several mAb directed against the beta chain of the IL-2 receptor, but not by antibodies to a number of other cell receptors ...
Carol A. Nacy, Miodrag Belosevic
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Constant-infusion recombinant interleukin-2 in adoptive immunotherapy of advanced cancer.
New England Journal of Medicine, 1987Adoptive immunotherapy involving bolus-dose recombinant interleukin-2 (rIL-2) has been reported to induce tumor regression in some patients with cancer, but has been associated with severe fluid retention and cardiopulmonary stress.
W. West +6 more
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Interleukin-2 receptor expression and interleukin-2 production in bullous pemphigoid
Archives of Dermatological Research, 1990Expression of interleukin-2 (IL2) receptors was studied on peripheral blood lymphocytes (PBLs) in 25 patients with bullous pemphigoid. Analysis was carried out by flow cytometry. Without immunosuppressive therapy expression of IL2 receptors only on T cells (CD5) was significantly increased as shown by double staining (11.9% +/- 7.8% vs 2.1% +/- 1% in ...
M. Ladusch +3 more
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Cancer Immunotherapy Using Interleukin-2 and Interleukin-2-Activated Lymphocytes
Annual Review of Immunology, 1986The development of immunologic approaches to the treatment of cancer has progressed through major changes in the past five years. In the 1970s considerable enthusiasm existed for immunotherapeutic approaches to cancer based on attempts to provide nonspecific stimulation of the host immune system in the hope that this general increase in immune reactivÂ
M T Lotze, S A Rosenberg
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The released interleukin 2 receptor binds interleukin 2 efficiently.
The Journal of Immunology, 1986Abstract The released interleukin 2 receptor (IL 2R) molecule was characterized in order to clarify its biochemical structure and to determine its functional capacity. Enzymatic digestions demonstrated that the released IL 2R, like the cell surface IL 2R, is a complex glycoprotein, modified by the addition of both N- and O-linked ...
L A, Rubin, G, Jay, D L, Nelson
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Pathology, 1991
Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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Journal of the American Medical Association (JAMA), 1994
OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma or renal cell cancer.
S. Rosenberg +8 more
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OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma or renal cell cancer.
S. Rosenberg +8 more
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The interleukin-2/interleukin-2 receptor system: structural, immunological, and clinical features
International Journal of Clinical & Laboratory Research, 1992Interleukin-2 (IL-2) has been the first and more extensively studied cytokine, in particular for its central role in the mechanisms of cell growth and differentiation. The function of IL-2 is mediated through specific receptors (IL-2R) present on the membrane of reacting cells.
SEMENZATO, GIANPIETRO CARLO +2 more
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Journal of the National Cancer Institute, 1994
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of cancer have demonstrated that cellular immune reactions against established malignancy exist in humans.
S. Rosenberg +9 more
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BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of cancer have demonstrated that cellular immune reactions against established malignancy exist in humans.
S. Rosenberg +9 more
semanticscholar +1 more source