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Physiologic roles of interleukin-2, interleukin-4, and interleukin-7
Current Opinion in Hematology, 1996The use of gene targeting techniques has led to new insights into the physiologic function of lymphoid growth factors, their receptors, and associated signal transduction molecules in the formation and function of T and B cells. Mice rendered deficient for the growth factors interleukin-2 or interleukin-4 exhibit impairment in certain immune responses ...
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Emerging Drugs, 2000
The development of recombinant interleukin-2 (rIL-2) as a treatment for cancer represented an important milestone in the development of biologic therapies. IL-2 is a natural modulator of the immune system that stimulates specialised immune system cells, namely cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKCs). These cells could potentially
Anagha Gurjal, Philip Agop Philip
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The development of recombinant interleukin-2 (rIL-2) as a treatment for cancer represented an important milestone in the development of biologic therapies. IL-2 is a natural modulator of the immune system that stimulates specialised immune system cells, namely cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKCs). These cells could potentially
Anagha Gurjal, Philip Agop Philip
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Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.
Science, 1995In mice lacking the interleukin-2 receptor beta chain (IL-2R beta), T cells were shown to be spontaneously activated, resulting in exhaustive differentiation of B cells into plasma cells and the appearance of high serum concentrations of immunoglobulins ...
H. Suzuki +9 more
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Interleukin-2, Autotolerance, and Autoimmunity
1991Insomma se il modello non riesce a trasformare la realta, la realta dovrebbe riuscire a trasformare il modello…. Se le cose stanno cosi, il modello dei modelli dovra servire a ottenere dei modelli trasparenti, diafani, sottili como ragnatele; magari addiritura a dissolvere i modelli, anzi a dissolversi.
José Luis Andreu +4 more
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1985
Publisher Summary This chapter describes certain approaches, which are most useful in the purification and characterization of human IL-2 and which have general applicability throughout the lymphokine field. Interleukin 2 (IL-2, T cell growth factor) is situated at the center of the cascade of antigen-nonspecific factors released during an immune ...
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Publisher Summary This chapter describes certain approaches, which are most useful in the purification and characterization of human IL-2 and which have general applicability throughout the lymphokine field. Interleukin 2 (IL-2, T cell growth factor) is situated at the center of the cascade of antigen-nonspecific factors released during an immune ...
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1998
Die Zellen des Immunsystems, die innerhalb eines Organismus fur die Abwehr von Bakterien, Viren, Pilzen und anderen schadlichen Einflussen zustandig sind, „verstandigen“ sich untereinander auf chemischem Wege. Das heist, sie produzieren eine Vielzahl verschiedener Stoffe, die ins Blut abgegeben werden und fur andere Zellen Signalfunktion haben ...
Hilke Stamatiadis-Smidt +1 more
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Die Zellen des Immunsystems, die innerhalb eines Organismus fur die Abwehr von Bakterien, Viren, Pilzen und anderen schadlichen Einflussen zustandig sind, „verstandigen“ sich untereinander auf chemischem Wege. Das heist, sie produzieren eine Vielzahl verschiedener Stoffe, die ins Blut abgegeben werden und fur andere Zellen Signalfunktion haben ...
Hilke Stamatiadis-Smidt +1 more
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The role of interleukin-2 during homeostasis and activation of the immune system
Nature reviews. Immunology, 2012O. Boyman, J. Sprent
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