Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
What Is the Role of Industry-Based Intermediary Organisations in Supporting Workplace Mental Health in Australia? A Scoping Review. [PDF]
Int J Environ Res Public HealthBurns K +4 more
europepmc +1 more source
Knowledge brokers the role of intermediaries in producing research impact:the role of intermediaries in producing research impact [PDF]
, 2013 Knight, Christine, Lyall, Catherine
core +1 more source
What Do Financial Intermediaries Do? [PDF]
This paper presents evidence that the traditional banking business of accepting deposits and making loans has declined significantly in the US in recent years. There has been a switch from directly held assets to pension funds and mutual funds.
Anthony M. Santomero, Franklin Allen
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Leveraging intermediaries' skillsets to build implementation research and practice infrastructure: a qualitative case study. [PDF]
Implement Sci CommunBrooks SP +6 more
europepmc +1 more source
'Fair Trade' Coffee and the Mitigation of Local Oligopsony Power [PDF]
In recent years there has been considerable growth in ‘Fair Trade’ markets for several commodities, but most notably for coffee. We argue that coffee is grown under conditions that might well subject growers to the market power of intermediaries.
Donald MacLaren +2 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Impact of Occlusal Overloads on Complications in Fixed Prosthetic Dentures. [PDF]
J Clin MedVlăduțu DE +11 more
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source