Results 171 to 180 of about 102,407 (245)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Single cell resolution of neurosteroidogenesis in the murine brain: intermediary biosynthesis. [PDF]

J Endocrinol
Koganti PP, Selvaraj V.
europepmc   +1 more source

Intermediaries in the Supply Chain : A categorization of intermediaries with regards to their relationships, involvement and power.

, 2018
Hanna Borker, Julia Nastl
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Health disparities in complicated lower respiratory tract infections: a population-based cohort study in The Hague, The Netherlands. [PDF]

BMJ Public Health
van Dokkum ED, Sijbom M, le Cessie S, Mook-Kanamori DO, Bruijnzeels MA, van der Schoor AS, Te Paske K, Langeveld K, Visser LG, Numans ME, van Nieuwkoop C, Borgdorff H.   +11 more
europepmc   +1 more source

<p>A Comparative Analysis of Intermediary Liability in Defamation Cases: A Cursory Look at the Position in Australia, United States of America, the United Kingdom, India and Nigeria</p>

Irene Momoh
openalex   +1 more source

Global Financial Crisis and Risk Management in Financial Intermediaries: Is it White Page?

, 2011
Yener Çoşkun, Murad Kayacan
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

What Is the Role of Industry-Based Intermediary Organisations in Supporting Workplace Mental Health in Australia? A Scoping Review. [PDF]

Int J Environ Res Public Health
Burns K, Ellis LA, De Almeida Neto A, Lopes CVA, Amin J.   +4 more
europepmc   +1 more source

Ethics and Rules of Conduct of the Financial Intermediaries

, 2014
Mirella Pellegrini
openalex   +1 more source