Results 241 to 250 of about 206,403 (340)

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Mechanistic Elucidation and Stereochemical Consequences of Alternative Binding of Alkenyl Substrates by Engineered Arylmalonate Decarboxylase. [PDF]

J Am Chem Soc
van der Pol E, Schlatzer T, Hoffka G, Di Geronimo B, Eder J, Schweiger AK, Karava M, Gross D, Fischer RC, Kracher D, Kazlauskas R, Miyamoto K, Kamerlin SCL, Breinbauer R, Kourist R.   +14 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Emergence of Calabi-Yau manifolds in high-precision black-hole scattering. [PDF]

Nature
Driesse M, Jakobsen GU, Klemm A, Mogull G, Nega C, Plefka J, Sauer B, Usovitsch J.   +7 more
europepmc   +1 more source

Search for gravitational waves from intermediate mass binary black holes [PDF]

, 2012
J. Abadie, B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, T. Accadia, F. Acernese, C. Adams, R. X. Adhikari, C. Affeldt, M. Agathos, K. Agatsuma, P. Ajith, B. Allen, E. Amador Ceron, D. Amariutei, S. B. Anderson, W. G. Anderson, K. Arai, M. A. Arain, M. Araya, S. M. Aston, P. Astone, D. Atkinson, P. Aufmuth, C. Aulbert, B. E. Aylott, S. Babak, P. T. Baker, G. Ballardin, S. Ballmer, J. C. Barayoga, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, M. A. Barton, I. Bartos, R. Bassiri, M. Bastarrika, A. Basti, J. C. Batch, J. Bauchrowitz, Thomas Bauer, M. Bebronne, D. Beck, B. Behnke, M. Bejger, M. G. Beker, A. S. Bell, A. Bellétoile, Ilya Belopolski, M. Benacquista, J. M. Berliner, A. Bertolini, J. Betzwieser, N. Beveridge, P. T. Beyersdorf, I. A. Bilenko, G. Billingsley, J. Birch, R. Biswas, M. Bitossi, M. A. Bizouard, E. Black, J. K. Blackburn, Lindy Blackburn, D. G. Blair, B. Bland, M. Blom, O. Bock, T. P. Bodiya, C. Bogan, R. Bondarescu, F. Bondu, L. Bonelli, R. Bonnand, R. Bork, M. Born, V. Boschi, S. Bose, L. Bosi, B. Bouhou, S. Braccini, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, J. E. Brau, J. Breyer, T. Briant, D. O. Bridges, A. Brillet, M. Brinkmann, V. Brisson, M. Britzger, A. F. Brooks, D. Brown, T. Bulik   +99 more
openalex   +1 more source

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

Advanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu, Siyuan Chang, Zhaoheng Zhang, Tianqi Kang, Mingde Liu, Yuan Zong, Fei Ni, Yinguang Bao, Ruijie Zhang, Xiaobang Zhang, Jinkun Du, Mingming Xin, Zhaorong Hu, Jie Liu, Zhongfu Ni, Qixin Sun, Yingyin Yao   +16 more
wiley   +1 more source

Attosecond spectroscopy of molecular charge transfer uncovers a 1.5-fs delay in population transfer. [PDF]

Nat Commun
Matselyukh DT, Rott F, Schnappinger T, Zhang P, Li Z, Richardson JO, de Vivie-Riedle R, Wörner HJ.   +7 more
europepmc   +1 more source

Organic Electrochemical Transistors in Tissue‐Interfaced Bioelectronics

Advanced Science, EarlyView.
This article reviews the design, fabrication, and biological application of organic electrochemical transistors (OECTs), emphasizing their potential in tissue‐interfaced bioelectronics. It covers the fundamental principles of OECTs, strategies for enhancing tissue interfacing, and the development of skin‐mounted and implantable systems.
Ruixiang Bai, Zeyu Zhao, Feng Yan
wiley   +1 more source

Research progress in photochemical synthesis of urea through C-N coupling reactions. [PDF]

RSC Adv
Yang Z, Li P.
europepmc   +1 more source

NIR‐Triggered Upconversion‐Perovskite Heterostructures for Non‐Genetic, Implant‐Free Optoelectronic Neuromodulation

Advanced Science, EarlyView.
The Single‐Nanostructured Optoelectronic Vehicle for neuromodulation Activation (SNOVA) establishes a paradigm for non‐genetic, implant‐free neuromodulation. By integrating NIR‐excitable UCNPs with broadband‐absorbing perovskite QDs, SNOVA efficiently converts deeply penetrating light into localized electric fields that modulate neuronal ion dynamics ...
Luyue Jiang, Chenguang Ma, Yiping Zhao, Jiazhi Li, Gen Li, Shuang Jin, Haoyang Su, Ye Tian, Yingkang Yang, Yunfu Luo, Lei Huang, Peijie Chen, Yiming Gao, Yi Wei, Yike Xiang, Lunming Qin, Kaihuan Zhang, Yifei Ye, Pengyi Tang, Liuyang Sun   +19 more
wiley   +1 more source