Results 121 to 130 of about 3,959,588 (324)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Microphallus pseudopygmaeus (Digenea) infects phylogenetically distant gastropods, with signs of host-linked genetic divergence

Parasite
Host-switching between distantly related host species offers rare insight into how parasites overcome compatibility barriers and initiate evolutionary divergence.
Sokolova Alina I., Galaktionov Kirill V., Gonchar Anna   +2 more
doaj   +1 more source

The Complete Mitochondrial Genome of Galba pervia (Gastropoda: Mollusca), an Intermediate Host Snail of Fasciola spp

PLoS ONE, 2012
Complete mitochondrial (mt) genomes and the gene rearrangements are increasingly used as molecular markers for investigating phylogenetic relationships.
Guo-Hua Liu, Shu-Yan Wang, Wei-yi Huang, Guang-Hui Zhao, Shujun Wei, Hui Song, Min-jun Xu, R. Lin, Dong‐Hui Zhou, Xing-Quan Zhu   +9 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Larval size in acanthocephalan parasites: Influence of intraspecific competition and effects on intermediate host behavioural changes

Parasites & Vectors, 2012
BackgroundParasites often face a trade-off between exploitation of host resources and transmission probabilities to the next host. In helminths, larval growth, a major component of adult parasite fitness, is linked to exploitation of intermediate host ...
Lucile Dianne, L. Bollache, C. Lagrue, Nathalie Franceschi, T. Rigaud   +4 more
semanticscholar   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The Host Galaxies of Gamma-Ray Bursts I: ISM Properties of Ten Nearby Long-Duration GRB Hosts

, 2009
We present the first observations from a large-scale survey of nearby (z < 1) long-duration gamma-ray burst (LGRB) host galaxies, which consist of eight rest-frame optical spectra obtained at Keck and Magellan.
Adelman-McCarthy, Asplund, Berger, Berger, Berger, Berger, Bloom, Brown, Chary, Chen, Cobb, Copetti, Dopita, Edo Berger, Emily M. Levesque, Erb, Fynbo, Garnett, Giavalisco, Graham, Hillier, Jansen, Jansen, Kawabata, Kennicutt, Kewley, Kewley, Kewley, Kewley, Kewley, Kobulnicky, Kocevski, Kudritzki, Kurucz, Langer, Leitherer, Leitherer, Levesque, Levesque, Lisa J. Kewley, Liu, Megan M. Bagley, Meynet, Modjaz, Osterbrock, Prochaska, Prochaska, Savaglio, Savaglio, Schaerer, Schaerer, Schaerer, Schaerer, Schlegel, Shapley, Soderberg, Stanek, Stanek, Stasinska, Stasinska, van Zee, Vàzquez, Wainwright, Wirth, Woosley   +64 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source