Results 51 to 60 of about 277,680 (262)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dynamics of Angiostrongylus cantonensis infection in invasive snails Biomphalaria straminea and Physa acuta from Guangdong, southern China

Parasitology
Biomphalaria straminea (Gastropoda: Planorbidae) and Physa acuta (Gastropoda: Physidae), both invasive species in southern China, are important vectors for zoonotic diseases.
Ping He, Jehangir Khan, Kefeng Jiang, Peiying Peng, Wanxian Huang, Benjamin Sanogo, Du Gao, Zhong-Dao Wu, Song Liang, Xi Sun, Datao Lin   +10 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Wild passerines as potential carriers and sources of avian influenza viruses in Ukraine

Frontiers in Microbiology
Wild waterfowl and shorebirds are the primary reservoir of influenza A viruses in nature. The role of wild birds from other taxonomic groups remains insufficiently studied or is a subject of debate.
Nataliia Muzyka, Anastasia Popova, Oleksandr Rula, Polina Yurko, Anzhela Chaplygina, Alexander M. P. Byrne, Abi Lofts, Siamak Zohari, Susanne Koethe, Jeanne Fair, Jen Owen, Nicola Lewis, Anne Pohlmann, Martin Beer, Jonas Waldenström, Denys Muzyka, Denys Muzyka   +16 more
doaj   +1 more source

Development of a Whole-Virus ELISA for Serological Evaluation of Domestic Livestock as Possible Hosts of Human Coronavirus NL63

Viruses, 2019
Known human coronaviruses are believed to have originated in animals and made use of intermediate hosts for transmission to humans. The intermediate hosts of most of the human coronaviruses are known, but not for HCoV-NL63.
Philip El-Duah, Benjamin Meyer, Augustina Sylverken, Michael Owusu, Lina Theresa Gottula, Richmond Yeboah, Jones Lamptey, Yaw Oppong Frimpong, Vitus Burimuah, Raphael Folitse, Olivia Agbenyega, Samuel Oppong, Yaw Adu-Sarkodie, Christian Drosten   +13 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Gnathostoma turgidum – still a mysterious parasite

Helminthologia
The recent publication entitled “Possible zoonotic implications of the discovery of the advanced third stage larva of Gnathostoma turgidum (Spirurida: Gnathostomatidae) in a Mexican fish species” by Mosqueda-Cabrera et al., appeared in Helminthologia ...
Nawa Y., Delgado-Vargas F., Díaz-Camacho S. P.   +2 more
doaj   +1 more source

Molecular detection of Sarcocystis spp. and Toxoplasma gondii in wild macaws (Ara ararauna) rescued from illegal trade in Brazil

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Bird species participate in the life cycle and epidemiology of sarcocyst organisms, but the number of involved species remains unclear; thus, the importance of wild macaws as intermediate hosts needs to be elucidated. This study aimed to identify members
G.V.A. Samoel, G. Rosa, F.D. Fernandes, J.F. Cargnelutti, F.S. F. Vogel   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source