Results 101 to 110 of about 1,169,476 (247)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Elimination of Schistosoma japonica in Central Sulawesi, Indonesia Intermediate Snail Control and Utilization Medicinal Plants

Journal of Parasite Science
Schistosomiasis is a zoonotic health problem caused by infection with the schistosoma class parasite, which lives in human blood vessels and around the intestines and bladder.
Acivrida Mega Charisma, Anjelline Naftalia, Alfian Anwar Putra Ramadhan, Rasyida Salma Aulia, Ferdina Amalia Solikhah, Husnul Muasyaroh, Vina Lailatul Maslakha, Nurul Hikmah, Ken Dyah Ayu Belina, Hilda Adinda, Siska Wulandari   +10 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Taenia pisiformis Bloch, 1780 (Cestoda) as an endoparasite of mammals

Acta Biologica Sibirica
Taenia pisiformis is a cosmopolitan cestode of considerable veterinary importance, circulating between carnivorous definitive hosts and lagomorph intermediate hosts.
Abat S. Berdibaev, Sardorbek N. Turgunov, Erkinjon B. Shakarboev, Bakhytgul Kh. Shaikhova, Sherali A. Abdurakhmonov, Aybek A. Urgenichbaev, Guzal A. Khosilova   +6 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Non-native gobies facilitate the transmission of Bucephalus polymorphus (Trematoda)

Parasites & Vectors, 2015
Background Introduced species can modify local host-parasite dynamics by amplifying parasite infection which can ‘spill-back’ to the native fauna, whether they are competent hosts for local parasites, or by acting as parasite sinks with ‘dilution’ of ...
Markéta Ondračková, Iveta Hudcová, Martina Dávidová, Zdeněk Adámek, Martin Kašný, Pavel Jurajda   +5 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Two important snail intermediate hosts, Bithynia fuchsiana and Melanoides tuberculata and a Parapleurolophocercous cercaria (Photos by Henry Madsen).

, 2013
Two important snail intermediate hosts, Bithynia fuchsiana and Melanoides tuberculata and a Parapleurolophocercous cercaria (Photos by Henry Madsen).
Anders Dalsgaard (292655), Hung Nguyen Manh (292653), Khue Nguyen Viet (292654), Jesper Hedegaard Clausen (292650), Henry Madsen (292651), Van Phan Thi (292652), K. Darwin Murrell (267756)   +6 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source