Results 231 to 240 of about 2,358,795 (346)

Beyond the surface of capacity building: a mixed-methods study of the core functions and forms of dissemination and implementation science consultations. [PDF]

open access: yesImplement Sci Commun
Swanson KN   +12 more
europepmc   +1 more source

Cut‐Enabled Mechanical Metamaterials for Multimodal and Reprogrammable Static Nonreciprocity

open access: yesAdvanced Science, EarlyView.
Cut‐enabled mechanical metamaterials are designed to overcome the challenge of obtaining multiple and reprogrammable static nonreciprocal modes in a single microstructural topology. It offers a pathway to synthesize multiple nonreciprocal modes and control the nonreciprocal responses, enhancing the functionality of metamaterials.
Jinhao Zhang   +8 more
wiley   +1 more source

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

open access: yesAdvanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang   +6 more
wiley   +1 more source

Personalized Medication for Chronic Diseases Using Multimodal Data‐Driven Chain‐of‐Decisions

open access: yesAdvanced Science, EarlyView.
A MDD‐CoD is proposed for personalized chronic disease medication. The framework simulates clinical chain‐of‐decisions through three linked deep learning tasks, validated on multi‐center datasets (3 hospitals, 4 diseases), demonstrating enhanced generalization and interpretability in cross‐disease applications.
Xiaoli Chu   +10 more
wiley   +1 more source

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

open access: yesAdvanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox   +9 more
wiley   +1 more source

Electron Transfer‐Tailored D‐Band Center to Boost Nanozyme Catalysis for Interpretable Machine Learning‐Empowered Intelligent Biosensing

open access: yesAdvanced Science, EarlyView.
This study pioneers a rational nanozyme design strategy guided by electron transfer mechanisms while advancing biosensing paradigms through interpretable machine learning‐enhanced signal intelligence. By transforming biosensors from passive transducers to active diagnostic systems, this work establishes a versatile framework for addressing global ...
Yuechun Li   +9 more
wiley   +1 more source

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