Results 251 to 260 of about 2,358,795 (346)

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

Advanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan, Yinuo Liu, Lu‐ping Chi, Chaofan Yang, Shengying Li, Wei Zhang   +5 more
wiley   +1 more source

A sequence-activated near-infrared fluorescence probe for precisely tracking <i>in vivo</i> senescence. [PDF]

Chem Sci
Nong J, Li P, Zhu M, Li Y, Wang C, Zhang Y, Yan C, Guo Z.   +7 more
europepmc   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source

Tuning Ultrasensitivity in Genetic Logic Gates Using Antisense RNA Feedback. [PDF]

ACS Synth Biol
Engelmann N, Molderings M, Koeppl H.
europepmc   +1 more source

A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis

Advanced Science, EarlyView.
This study presents RotEx‐LAMP‐LFA, a fully integrated, battery‐powered, low‐cost point‐of‐care device for rapid cervical cancer risk detection based on HPV16/18 E6/E7 mRNA. Clinically validated, the system demonstrated high sensitivity and specificity, and showed full concordance between self‐collected and clinician‐collected samples, offering a ...
Yuan Gao, Qiang Wen, Siyuan Qiao, Linyi Deng, Keyue Li, Zhuyan Shao, Xiaonan Liu, Tao Zhu, Chao Zhang, Da Han, Weihong Tan   +10 more
wiley   +1 more source

An area and power efficient ternary serial adder using phase composite ZnO stack channel FETs. [PDF]

Nanoscale Adv
Kim K, Kim S, Kim SY, Lee Y, Lee HW, Kang S, Lee BH.   +6 more
europepmc   +1 more source

Bacteria‐Targeted Single‐Atom Nanozyme With Photothermal‐Augmented Multi‐Enzymatic Cascade and NO Delivery for Enhanced Infected Wound Healing

Advanced Science, EarlyView.
A single‐atom nanozyme‐based multifunctional nanoplatform synergizes bacterial targeting with a NIR‐II responsive therapeutic cascade for effective diabetic wound management. This nanoplatform enhances biofilm destruction through photothermal‐augmented biocatalysis while simultaneously activating endothelial cells by delivering nitric oxide to promote ...
Junyang Chen, Qing Chen, Xudong Qin, Haixia Yang, Xin Wang, Jianliang Zhou, Ying‐Wei Yang, Jian Tian   +7 more
wiley   +1 more source

Beyond PlasticSurgeryGPT: The Imperative for Reasoning-Enhanced Large Language Models in Plastic Surgery. [PDF]

Aesthet Surg J
Ray PP.
europepmc   +1 more source

Bio‐Inspired Stored Magnetic Energy Actuator with Transient Triggering and Programmable Logic

Advanced Science, EarlyView.
A bio‐inspired magnetic energy actuator achieves 1.6 m/s transient release—three orders faster than conventional systems—via direct ink writing printed NdFeB/Polydimethylsiloxane composites and environmental locks; biomimetic AND‐gate logic enables sequential cue recognition (e.g., “temperature → rainfall”).
Chao Xu, Shuo Jiang, Lu Zhang, Xueli Zhou, Qingping Liu, Luquan Ren   +5 more
wiley   +1 more source

Robotic Materials With Bioinspired Microstructures for High Sensitivity and Fast Actuation

Advanced Science, EarlyView.
In the review paper, design rationale and approaches for bioinspired sensors and actuators in robotics applications are presented. These bioinspired microstructure strategies implemented in both can improve the performance in several ways. Also, recent ideas and innovations that embed robotic materials with logic and computation with it are part of the
Sakshi Sakshi, Rohit Pratyush Behera, Hongyu Zhou, Yifan Wang, Hortense Le Ferrand   +4 more
wiley   +1 more source