Results 41 to 50 of about 455,476 (286)

Skolemization In Intermediate Logics

open access: yesCoRR
Skolemization, with Herbrand's theorem, underpins automated theorem proving and various transformations in computer science and mathematics. Skolemization removes strong quantifiers by introducing new function symbols, enabling efficient proof search algorithms.
Matthias Baaz   +3 more
openaire   +2 more sources

Applications of Intuitionistic Logic in Answer Set Programming [PDF]

open access: yes, 2003
We present some applications of intermediate logics in the field of Answer Set Programming (ASP). A brief, but comprehensive introduction to the answer set semantics, intuitionistic and other intermediate logics is given.
Arrazola, Jose   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Sequent Calculus in the Topos of Trees

open access: yes, 2015
Nakano's "later" modality, inspired by G\"{o}del-L\"{o}b provability logic, has been applied in type systems and program logics to capture guarded recursion. Birkedal et al modelled this modality via the internal logic of the topos of trees. We show that
A. Bizjak   +13 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

The curious case of COVID-19: Its murky origin, negligence and a botched international attempt for a cover-up

open access: yesAsian Journal of Medical Sciences, 2021
COVD-19 caused due to SARS-CoV2, family of Coronaviridae, the order Nidovirales, and the genus Coronavirus. A zoonotic spillover infection from bats to humans through some intermediate host was proposed to be responsible for its origin.
Ruby Dhar   +5 more
doaj   +1 more source

Preservation of admissible rules when combining logics

open access: yes, 2016
Admissible rules are shown to be conservatively preserved by the meet-combination of a wide class of logics. A basis is obtained for the resulting logic from bases given for the component logics.
Rasga, Joao   +2 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Towards a mental probability logic

open access: yesPsychologica Belgica, 2005
We propose probability logic as an appropriate standard of reference for evaluating human inferences. Probability logical accounts of nonmonotonic reasoning with SYSTEM P, and conditional syllogisms (MODUS PONENS, etc.) are explored.
Niki Pfeifer, Gernot D. Kleiter
doaj   +1 more source

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