Results 41 to 50 of about 3,184,608 (250)
‘Resources to Needs’: A Paradigm for Addressing the Potentiality of the Urban Volume
Urban Planning, 2017 Underground resources are often addressed only out of necessity, leading to conflicts between uses and missing opportunities for productive synergies.
Michael Robert Doyle
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Intermediate cities in Northwest Argentina as reflection of development models
Redes, 2018 In the context of aggressive neoliberal globalization, development –in a social as well as in an economic sense – represents a challenge for Latin-American countries.
Matilde Malizia +2 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Maximal traces and path-based coalgebraic temporal logics [PDF]
, 2011 This paper gives a general coalgebraic account of temporal logics whose semantics involves a notion of computation path. Examples of such logics include the logic CTL* for transition systems and the logic PCTL for probabilistic transition systems.
Cirstea, Corina, Corina Cîrstea
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La gestion des déchets post-catastrophe à Port-au-Prince : entre relégation et proximité
EchoGéo, 2014 Waste-disaster production is often considerate less urgent or less important than access to health or water. However, it may be central in recovery and reconstruction process of the affected area.
Roxana Popescu +2 more
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Kripke completeness for intermediate logics [PDF]
, 2000 The thesis studies problems in model theory for nonclassical logics, more specifically, for intermediate propositional logics. This area was opened in the 1930s by the well-known works of Gödel and Tarski and has now evolved into an interesting and ...
C. Fiorentini
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