Results 61 to 70 of about 789,942 (260)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

الدور التربوي للأسرة السعودية في تنمية المهارات الأساسية المتوسطة لدى أفرادها من وجهه نظر الآباء والأمهات [PDF]

مجلة العلوم التربوية - کلية التربية بقنا
ملخص الدراسةهدفت هذه الدراسة إلى الوقوف على المهارات الأساسية المتوسطة التي ينبغي أن يلم بها أفراد الأسرة من وجهة نظر الخبراء، والتعرف على واقع الدور التربوي للأسرة السعودية في تنمية المهارات الأساسية المتوسطة لدى أفرادها من وجهة نظر الآباء والأمهات في ...
فهد بن صالح بن ابراهيم الحضيف
doaj   +1 more source

Properties of the intermediate point from the Taylor's theorem [PDF]

Mathematical Inequalities & Applications, 2009
If I ⊆ R is an interval, a ∈ I and f : I → R is n 1 times differentiable on I , then, in view of Taylor’s theorem, there exists a function c : I → I such that, for each x ∈ I, f (x) = n−1 ∑ k=0 f (k) (a) k! (x−a) + f (n) (c(x)) n! (x−a) . In this paper we study the behaviour of the derivatives c(p) and θ (p) of the functions c and θ , respectively ...
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Carotid Artery Wall Alterations as Intermediate End Points

Clinical and Experimental Hypertension, 1999
Carotid artery wall alterations can now be measured in a quantitative, well reproducible way by B-mode ultrasound. The thickness of the intima-media complex (IMT) is commonly measured at three levels along the carotid tree. Well standardized protocols to use in randomized prospective trials are available.
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Three-Way Handshake for Intermediate System to Intermediate System (IS-IS) Point-to-Point Adjacencies. [PDF]

RFC, 2002
Dave Katz, Rajesh Saluja
openaire   +2 more sources