Results 121 to 130 of about 453,245 (300)
Double polarization experiments at intermediate energy [PDF]
Nuclear Physics A, 2000 At modern electron accelerators with highly polarized, intense, high duty factor beams double polarization coincidence experiments became feasible with good statistical accuracy. The strong potential towards the precise determination of small nucleon structure quantities is illustrated by two recent examples from MAMI. The measurement of $G_E^n$ in the
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Astrophysical JournalWe study the effects of general relativity (GR) on the evolution and alignment of circumbinary disks around binaries on all scales. We implement relativistic apsidal precession of the binary into the hydrodynamics code phantom .
Anna C. Childs +6 more
doaj +1 more source
The effects of tidally induced disc structure on white dwarf accretion in intermediate polars
, 1998 We investigate the effects of tidally induced asymmetric disc structure on accretion onto the white dwarf in intermediate polars. Using numerical simulation, we show that it is possible for tidally induced spiral waves to propagate sufficiently far into ...
Armitage, P. J. +3 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Twisted accretion curtains in the intermediate polar FO Aquarii
, 2003 We report on a ~37-ks XMM-Newton observation of the intermediate polar FO Aquarii, presenting X-ray and UV data from the EPIC and OM cameras. We find that the system has changed from its previously reported state of disc-overflow accretion to one of ...
Aizu +37 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
, 2009 A significant number of cataclysmic variables were detected as hard X-ray sources in the INTEGRAL survey, most of them of the magnetic intermediate polar type.
Aizu +60 more
core +3 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source