Results 141 to 150 of about 521,909 (335)

Intermittent disturbance mechanical behavior and fractional deterioration mechanical model of rock under complex true triaxial stress paths

open access: yesInternational Journal of Mining Science and Technology
Mechanical excavation, blasting, adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass, leading to further fracture of damaged surrounding rock in three-dimensional high-stress and even causing ...
Zhi Zheng   +5 more
doaj   +1 more source

How important is the intermediate principal stress component for underground rock engineering?

open access: yesGeoEnergy Communications
Abstract  Approaches in rock engineering practice are empirical, analytical, and numerical. All of them overlook the significance of the intermediate principal stress component, which may give inaccurate stability assessment results. A novel three-dimensional elasto-plastic model, an extension of the classical Hoek–Brown model known as the ...
Duncan Maina   +4 more
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Elastoplastic analysis on deformation and failure characteristics of surrounding rock of soft-coal roadway based on true triaxial loading and unloading tests

open access: yesScientific Reports
Since accidents such as roof caving, rock fragmentation, and severe deformation are particularly likely to occur during roadway excavation in soft and thick coal seams, grasping the range and distribution of deformation and fracturing of surrounding rock
Chongyang Jiang   +3 more
doaj   +1 more source

Experimental Study on Energy Release Mechanism and Crack Propagation Evolution of Sandstone under True Triaxial Loading

open access: yesApplied Sciences
The instability of hard and brittle rock often leads to disastrous consequences in underground engineering. Under various surrounding rock pressure conditions, in situ stress induces corresponding deformation and damage to the floor post-mining ...
Shichuan Zhang   +2 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Experimental study on failure evolution mechanism of clastic rock considering cementation and intermediate principal stress

open access: yesJournal of Rock Mechanics and Geotechnical Engineering, 2022
Feiyan Wang   +3 more
semanticscholar   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

open access: yesFEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah   +8 more
wiley   +1 more source

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