Results 161 to 170 of about 1,450 (209)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Intermediate Representations in Imperative Compilers

ACM Computing Surveys, 2013
Compilers commonly translate an input program into an intermediate representation (IR) before optimizing it and generating code. Over time there have been a number of different approaches to designing and implementing IRs. Different IRs have varying benefits and drawbacks.
Des Watson
exaly   +3 more sources

An Abstract Intermediate Representation in Compilation Systems

ACM SIGPLAN Notices, 2003
The design of an intermediate representation is critical to the portability of a compiler and the efficiency of code generation. In order to increase the reusability of compiler components, and to simplify the development process of compilers, the paper presents an abstract intermediate representation (AIR) that provides a concise notation for ...
Weidu Jiang
exaly   +3 more sources

Engineering a customizable intermediate representation

Proceedings of the 2003 workshop on Interpreters, virtual machines and emulators, 2003
The Ovm framework is a set of tools and components for building language runtimes. We present the intermediate representation and software design patterns used throughout the framework. One of the main themes in this work has been to support experimentation with new linguistic constructs and implementation techniques.
Krzysztof Palacz, Jason Baker, Chapman Flack, Christian Grothoff, Hiroshi Yamauchi, Jan Vitek   +5 more
openaire   +1 more source

Intermediate depth representations

Artificial Intelligence in Medicine, 1992
The limitations of shallow representations have in part driven AI researchers to focus on deeper representations of knowledge. While deep representations solve some problems, they come at a computational cost. This paper focuses on the computational and representational advantages that may exist in using representations whose depth is intermediate ...
openaire   +2 more sources

An intermediate representation for behavioral synthesis

27th ACM/IEEE Design Automation Conference, 1990
This paper describes an intermediate representation for behavioral and structural designs that is based on annotated state tables. It facilitates user control of the synthesis process by allowing specification of partially design structures, and a mixture of behavior, structure and user specified bindings between the abstract behavior and the structure.
Nikil D. Dutt, Tedd Hadley, Daniel Gajski   +2 more
openaire   +1 more source