Results 81 to 90 of about 2,312,469 (251)

Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases

Journal of Immunology Research, 2015
Purpose. Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis. Methods.
Lindner Ewald, Langner-Wegscheider Beate, Sarny Stephanie, Renner Wilfried, El-Shabrawi Yosuf   +4 more
doaj   +1 more source

Exome Sequencing Uncovers Phenotypic and Genotypic Heterogeneity in 196 Indian Families Evaluated for Autoinflammatory Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autoinflammatory disorders (AIDs) are a clinically heterogeneous group of inborn errors of immunity primarily caused by dysregulation in the innate immune system. Clinical diagnosis is often challenging due to clinical heterogeneity and the overlapping phenotypes with other inborn errors of immunity and monogenic conditions that mimic AIDs ...
Vaishnavi Ashok Badiger, Periyasamy Radhakrishnan, Suma Balan, Anand P. Rao, Prajna Udupa, Karthik Vijay Nair, Bhagesh Hunakunti, Adarsh Pooradan Prasannakumar, Sanket Limaye, Huzail Gani Shaikh, Rohit Naik, Mahesh Janarthanan, Sudharshan Sridharan, Vishal Sondhi, Sheela Nampoothiri, Hitesh Shah, Sabrinath Mahadevan, Mahabaleshwar Mamadapur, Devang Pandya, Katta Mohan Girisha, Abhay Shivpuri, Amita Moirangthem, Jyothi Raghuram, Gandham Sri Lakshmi Bhavani, Sachin Jeevanagi, Girish Subramaniam, Amita Aggarwal, Anju Shukla, Dhanya Lakshmi Narayanan   +28 more
wiley   +1 more source

Uveitis Related with Multiple Sclerosis [PDF]

, 2012
Pur po se: To evaluate the clinical findings and outcomes of uveitis in patients with multiple sclerosis (MS). Ma te ri al and Met hod: We retrospectively evaluated the medical records of eight MS patients who had presented with uveitis to the uveitis ...
Sirel Gür Güngör, Yonca Aydın Akova, Ebru Akar   +2 more
core   +1 more source

Tofacitinib for refractory uveitis and scleritis

American Journal of Ophthalmology Case Reports, 2019
Purpose: To report the successful use of tofacitinib in the treatment of refractory uveitis and scleritis. Observations: Two patients, one with scleritis and another with anterior and intermediate uveitis, presented with refractory disease after failure ...
Michael A. Paley, Humeyra Karacal, P. Kumar Rao, Todd P. Margolis, Jonathan J. Miner   +4 more
doaj   +1 more source

Construction and evaluation of a chronic arthritis animal model induced by persistent activation of toll‐like receptors via lipopolysaccharide stimulation

Animal Models and Experimental Medicine, EarlyView.
We constructed a novel systemic juvenile idiopathic arthritis mouse model (LC) by introducing sustained TLR4 activation into the collagen‐induced arthritis model. The LC model effectively recapitulates human sJIA‐like systemic inflammation while revealing a critical dissociation between systemic immune activation and joint damage.
Fengming Li, Qiang Luo, Xinglin Wu, Yuxiao Chen, Xuemei Tang   +4 more
wiley   +1 more source

Etiology and Anatomical Location of Uveitis—Prognostic Factors for Disease Course and Laterality

Life
Background: Uveitis encompasses a broad group of diseases with infectious and non-infectious etiologies, potentially leading to permanent and irreversible visual impairment.
Vesela Todorova Mitkova-Hristova, Marin Anguelov Atanassov   +1 more
doaj   +1 more source

Innovative PLA or PCL‐Based Ocular Implants Obtained From Tape Casting or Electrospinning for Sustained‐Release Dexamethasone

Journal of Applied Polymer Science, EarlyView.
PLA and PCL ocular implants prepared by tape casting and electrospinning provide sustained dexamethasone release with distinct release profiles governed by polymer type and processing method. The relationship between polymer structure, degradation behavior, and drug release demonstrates the potential of these fabrication techniques for controlled ...
Renata Bochanoski, Henrique Borba Modolon, Ronaldo Silveira, Januara Rodrigues, Tiago Bender Wermuth, Sabrina Arcaro, Oscar R. K. Montedo   +6 more
wiley   +1 more source

Clinical characteristics of intermediate uveitis in adult Turkish patients [PDF]

International Journal of Ophthalmology, 2015
AIM:To describe the clinical characteristics of Turkish patients with intermediate uveitis (IU) and to investigate the effect of clinical findings and complications on final visual acuity (VA).METHODS:We retrospectively analyzed the medical records of ...
Esra Kardes, Betül Ilkay Sezgin Akcay, Kansu Bozkurt, Cihan Unlu, Gurkan Erdogan, Gulunay Akcali   +5 more
doaj   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source