Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Platform gentrification: The production of urban inequalities in the on-demand city. [PDF]
Sequera J.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Greening clubs- the role of sport in Ireland's approach to local climate action. [PDF]
Boyle E.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Despite the ensemble scholarly exchange on health communication, social media, and translation, research has not fully explored all the domains of social media communication, whether individual or participatory, conceived during the pandemic ...
Dingkun Wang, Brian Yecies
doaj
Research Hotspots and Trends of Endoplasmic Reticulum Stress in Obesity From 2014 to 2024: A CiteSpace Visualization Analysis. [PDF]
Zhang X +5 more
europepmc +1 more source
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Oral health associates with frailty in Chinese older adults: a chain mediating model of sleep quality and depressive symptoms. [PDF]
Chen L, Song J, Zhou C, Su D.
europepmc +1 more source
Effect of a transcultural nursing course on improving the cultural competency of nursing graduate students in Korea: a before-andafter study [PDF]
Bae KE, Jeong GH.
europepmc +1 more source

