Results 41 to 50 of about 1,691 (156)

Progressive myoclonus epilepsy in Down syndrome with Alzheimer's disease: An 11‐year longitudinal study and proposed diagnostic red flags

Epilepsia Open, Volume 11, Issue 4, Page 1200-1213, August 2026.
Abstract Objective Individuals with Down syndrome (DS) face an ultra‐high risk of Alzheimer's disease (AD). Within this continuum, Progressive Myoclonus Epilepsy (PME) has emerged as a marker of advanced neurodegeneration. Building on our 2014 characterization of this syndrome, we aimed to define its long‐term natural history and pathological substrate.
Giuseppe d'Orsi, Ezio Calò, Maria Teresa Di Claudio, Carmela Pia Ferro, Umberto Costantino, Elio Perrone, Raffaela Rita Latino   +6 more
wiley   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

Efficacy of Sodium Valproate in the Treatment of Photosensitive Epilepsy (PSE) and the Probable Reasons for the Persistence of Occipital Spikes

The Scientific World Journal, 2004
Intermittent photic stimulation (IPS) in patients with photosensitive epilepsy (PSE) leads to EEG abnormalities, which include generalized discharges with spike and wave activity.
Ebere C. Anyanwu, John E. Ehiri, Andrew W. Campbell   +2 more
doaj   +1 more source

The Impact of Subglacial Drainage System Evolution and Glacier Lake Outburst on Arctic Fjord Macronutrient Dynamics

Journal of Geophysical Research: Biogeosciences, Volume 131, Issue 7, July 2026.
Abstract Global warming is amplified in the Arctic, accelerating glacier melt and freshwater runoff. At tidewater glaciers, runoff typically enters fjords at depth and generates buoyancy‐driven circulation that enhances glacier‐ocean exchanges of energy and matter, influencing macronutrient delivery and marine primary production.
Andreas Alexander, Livia Piermattei, Philipp Assmy, Andrea L. Popp, Ken Zhao, Nicolas Valiente, Guy D. Tallentire, Simon Filhol, Thomas V. Schuler, Ugo Nanni, Jack Kohler, Louise S. Schmidt, Léo Decaux, George Cowie, Allison Bailey, Riko Noormets, Pierre‐Marie Lefeuvre, Claire S. Earlie, Maarja Kruusmaa, Andy Hodson   +19 more
wiley   +1 more source

Low Chemical Weathering Intensity, Enhanced Erosion, and Euxinic Conditions Along the Norwegian Margin During the Paleocene‐Eocene Thermal Maximum

Paleoceanography and Paleoclimatology, Volume 41, Issue 7, July 2026.
Abstract The Paleocene–Eocene Thermal Maximum (PETM; ∼55.9 Ma) was a rapid global warming event marked by intensified hydrological cycling, enhanced continental weathering, and widespread ocean deoxygenation. Although the extent of anoxic basins during the PETM is relatively well documented, the contribution of high‐latitude continental weathering to ...
Anjana Gireesh Sandhya, Jack Longman, Torben Struve, Morgan T. Jones, Joost Frieling, Katharina Pahnke   +5 more
wiley   +1 more source

Urea provides an important nitrogen source for microbial populations in an ultraoligotrophic sea

Limnology and Oceanography, Volume 71, Issue 6, June 2026.
Urea is an organic nitrogen (N) compound directly utilized by both heterotrophic prokaryotes and some photoautotrophs. Reports of either ambient urea concentrations or urea uptake rates from the ultraoligotrophic eastern Mediterranean Sea are lacking. We investigated urea distribution and uptake in the upper water column in the Levantine basin during ...
Alon Blachinsky, Tal Ben Ezra, Shiran Gozali, Anat Tsemel, Dan Tchernov, Mark Altabet, Ilana Berman‐Frank, Michael David Krom   +7 more
wiley   +1 more source

Topographic aspects of photic driving in the electroencephalogram of children and adolescents

Brazilian Journal of Medical and Biological Research, 2004
The electroencephalogram amplitude spectra at 11 fixed frequencies of intermittent photic stimulation of 3 to 24 Hz were combined into driving "profiles" for 14 scalp points in 8 male and 7 female normal subjects aged 9 to 17 years.
Lazarev V.V., Infantosi A.F.C., Valencio-de-Campos D., Azevedo L.C. de   +3 more
doaj  

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Light and tidal inundation and exposure regulate the sensitivity of estuarine benthic greenhouse gas fluxes to warming and ocean acidification

Limnology and Oceanography, Volume 71, Issue 4, April 2026.
Abstract Coastal sediments are globally significant sources and sinks of greenhouse gases (GHGs), yet their contributions to climate feedbacks of warming and ocean acidification remain uncertain, in part due to limited understanding of short‐term variability.
Michelle N. Simone, Joanne M. Oakes, Kai G. Schulz, Bradley D. Eyre   +3 more
wiley   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source