Results 81 to 90 of about 22,685 (262)

Across species: A comparative perspective on red cell homeostasis and its influence on our understanding of human physiology and disease

British Journal of Haematology, EarlyView.
This review highlights how studies on animal red cells have enriched our understanding of the behaviour of those from humans. A comparative perspective has enhanced our knowledge of human red cell pathophysiology Summary This review emphasises how studies on animal red cells have enriched our understanding of the behaviour of those from humans.
Kathleen M. Connolly, Pengyi Ding, Rasiqh Wadud, David C. Rees, John N. Brewin, John S. Gibson   +5 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Patient-ventilator asynchrony in preterm infants on nasal intermittent positive pressure ventilation

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2018
Objective To describe the incidence of patient-ventilator asynchrony and different types of asynchrony in preterm infants treated with non-synchronised nasal intermittent positive pressure ventilation (nIPPV). Design An observational study was ...
Cornelia G de Waal, Ruud W van Leuteren, Frans H de Jongh, Anton H van Kaam, Gerard J Hutten   +4 more
openaire   +3 more sources

Respiratory dysfunction and fatal apnea during pilocarpine‐induced status epilepticus

Epilepsia, EarlyView.
Abstract Objective Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure‐related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine‐induced SE affects respiration in mice.
Chengsan Sun, Rachel Spera, John M. Williamson, Suchitra Joshi, Bhavya Guduru, Harini Ganabady, Jaideep Kapur   +6 more
wiley   +1 more source

Retrospective analysis of ventilation strategies for blunt pulmonary trauma patients: comparing the effectiveness of synchronized intermittent mandatory ventilation, continuous positive airway pressure, and pressure-controlled ventilation

Journal of the Pakistan Medical Association
Objective: To compare the efficacy of various ventilation approaches to the treatment of patient with patients with severe blunt chest trauma. Method: The retrospective study was conducted at the Cardiorespiratory Syndrome Ward of the First People's ...
Lanlan Wu, Yanhua Hu, Yanwen Lu
doaj   +1 more source

The Outcome of Death or Moderate-to-Severe Bronchopulmonary Dysplasia in Extremely Low Birth Weight Infants is Equivalent with Bilevel- or Ventilator-Delivered Nasal Intermittent Positive Pressure Ventilation [PDF]

, 2013
B Lemyre, D Millar, B Yoder, A Chiu, R Roberts, H Kirpalani   +5 more
openalex   +1 more source

Management of a diaphragmatic hernia using self‐locking knots

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old Thoroughbred gelding was presented with a history of severe colic signs that were non‐responsive to non‐steroidal anti‐inflammatory drugs. During initial evaluation, distended small intestine was observed, together with continued colic signs and a serosanguinous abdominocentesis sample.
A. Gillen, A. Shanklin, A. Graham, A. A. Alvarez, C. Baldwin   +4 more
wiley   +1 more source

Non-synchronized nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) after extubation in preterm infants with respiratory distress syndrome

Journal of Behçet Uz Children's Hospital, 2019
INTRODUCTION: To determine whether non-synchronized nasal intermittent positive pressure ventilation (NIPPV) reduces extubation failure, compared to nasal continuous positive airway pressure (NCPAP), in preterm infants with respiratory distress syndrome (
Özkan İlhan, Senem Alkan Özdemir, Sinem Akbay, Berat Kanar, Şeyma Memur, Meltem Bor, Esra Arun Özer   +6 more
doaj   +1 more source