Results 41 to 50 of about 1,015,010 (313)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Internal & External Parasite Control [PDF]

, 2006
This document discusses internal & external parasite control with information on treatment and includes a management ...
Clemson University. Cooperative Extension Service
core  

Formation of the system of strategic control as a direction of ensuring the financial security of the enterprise

Проблеми теорії та методології бухгалтерського обліку, контролю і аналізу, 2019
The article is devoted to the formation of elements of the system of strategic control as a direction of ensuring an adequate level of financial security of the enterprise.
I.V. Saukh, N.G. Vyhovska
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Adaptive Internal Model Control Based on Parameter Adaptation [PDF]

, 2022
In actual industrial control, many objects have the characteristics of large lag and time-varying parameters, which makes it difficult for traditional PID control to obtain satisfactory control effects.
Ahmad Taher Azar, Kamal, Nashwa Ahmad, Zhang, Yunfeng, Jianhong Wang, Azar, Ahmad Taher, Farah Ayad Abdulmajeed, Peng Chen, Ibraheem Kasim Ibraheem, Wang, Jianhong, Ibrahim A. Hameed, Chen, Peng, Abdulmajeed, Farah Ayad, Hameed, Ibrahim A., Yunfeng Zhang, Ibraheem, Ibraheem Kasim, Nashwa Ahmad Kamal   +15 more
core   +1 more source

The Effect of Attentional Focus of Supra-Postural Task on Performance and Learning of Postural Control in Girls Aged between 9 and 12 [PDF]

رشد و یادگیری حرکتی ورزشی, 2017
Postural control is one of the important abilities in daily life and sport activities of human beings and the importance of focus of attention is always discussed in this issue.
Nastaran Naderirad, Ali Akbar Jaberi Moghadam, Shahzad Tahmasebi Boroujeni   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The effect of internal audit function quality and internal audit contribution to external audit on audit fees

, 2015
Corporate governance mandates and listing rules identify internal audit functions (IAF) as a central internal control mechanism. External audits are expected to assess the quality of IAF before placing reliance on its work.
Mat Zain, Mazlina, Zaman, Mahbub, Zain, Mazlina Mat, Mohamed, Zulkifflee   +3 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source