New anatomical insight into the muscular structure of the anal canal: revealing Treitz muscle as a directional shift of the internal anal sphincter [PDF]
Annals of ColoproctologyPurpose Understanding the muscular structure of the anal canal is crucial for the diagnosis and treatment of anorectal diseases. Treitz muscle is a vital yet poorly understood component.
Satoru Muro +6 more
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The Japanese Extracted Herbal Medicine Daikenchuto Increases the Contractile Activity of the Internal Anal Sphincter Muscle in Conscious Dogs [PDF]
Journal of the Anus, Rectum and Colon, 2020 Objectives: This study aimed to elucidate the effect of the extract of daikenchuto (DKT), a Japanese Kampo medicine, on the contractile activity of the internal anal sphincter in conscious dogs.
Kotaro Maeda +2 more
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Proctalgia and constipation secondary to hypertrophic polyglucosan inclusion body myopathy of the internal anal sphincter: a case report [PDF]
Journal of Medical Case Reports, 2018 Background Hereditary polyglucosan inclusion body myopathy of the internal anal sphincter is a rare cause of proctalgia fugax and constipation. Treatment options are explored.
Ioanna G Panagiotopoulou +4 more
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Bioengineered Internal Anal Sphincter Derived From Isolated Human Internal Anal Sphincter Smooth Muscle Cells [PDF]
Gastroenterology, 2009 BACKGROUND & AIMS: The internal anal sphincter (IAS) is a specialized circular smooth muscle that maintains rectoanal continence. In vitro models are needed to study the pathophysiology of human IAS disorders. We bioengineered sphincteric rings from human IAS smooth muscle cells (SMC) and investigated their response to cholinergic stimulation as well ...
Sita Somara +3 more
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An Exploratory Study on the Contractile Effects of Hydroxy-α-Sanshool and Hydroxy-β-Sanshool, the Active Ingredients of Daikenchuto, on the Internal Anal Sphincter. [PDF]
J Anus Rectum Colon, 2023 Maeda K, Sasaki T.
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Internal anal sphincter augmentation and substitution. [PDF]
Gastroenterol Rep (Oxf), 2014 There is an increasing recognition of the importance of internal anal sphincter (IAS) dysfunction presenting as passive faecal incontinence. This problem may manifest after anal sphincterotomy or following the more minimally invasive operations for haemorrhoids, as well as with advancing age.
de la Portilla F.
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The Physiology, Pharmacology and Therapeutic Manipulation of the Internal Anal Sphincter [PDF]
Canadian Journal of Gastroenterology, 2002 Recent research into the physiology and pharmacology of the internal anal sphincter has elucidated the importance of this structure in health and disease.
Oliver M Jones +2 more
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Internal anal sphincter dysfunction in neurogenic faecal incontinence
Journal of British Surgery, 1993 Abstract Forty-eight patients of median age 57 years with neurogenic faecal incontinence and 44 normal subjects of median age 51 years underwent fine-wire anal sphincter electromyography and anal manometry. The median (interquartile range (i.q.r.)) internal anal sphincter (IAS) electromyogram frequency was 0·26 (0·21–0·32) Hz for ...
Ridzuan Farouk +4 more
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Control of Motility in the Internal Anal Sphincter. [PDF]
J Neurogastroenterol Motil, 2019 The internal anal sphincter (IAS) plays an important role in the maintenance of fecal continence since it generates tone and is responsible for > 70% of resting anal pressure. During normal defecation the IAS relaxes. Historically, tone generation in gastrointestinal muscles was attributed to mechanisms arising directly from smooth muscle cells, ie ...
Keef KD, Cobine CA.
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BDNF rescues aging-associated internal anal sphincter dysfunction.
Am J Physiol Gastrointest Liver Physiol, 2021 These studies demonstrate that brain-derived neurotropic factor (BDNF) rescues the aging-associated internal anal sphincter (IAS) dysfunction, characterized by a decrease in IAS tone, and increase in non-adrenergic noncholinergic relaxation. We determined the effects of BDNF on the basal and GPCR (TXA2 and ANG II)-stimulated IAS tone, and on NANC ...
Singh A, Rattan S.
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