Results 51 to 60 of about 31,486 (252)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Unveiling a Bulk WTaV Multicomponent Alloy With Superior Thermal Properties and Manufacturability

Advanced Science, EarlyView.
ABSTRACT Many tungsten (W)‐based medium and high entropy alloys (HEA) demonstrate superior microstructural stability and enhanced mechanical properties as compared to pure W, effectively rendering them as viable candidate materials for extreme environments such as nuclear fusion, aerospace applications, and so on.
Ishtiaque K. Robin, Skye N. Supakul, Shalini Tripathi, Eda Aydogan, Matthew T. Vigil, Caleb Hatler, Bochuan Sun, Akshay Korpe, Enrique Martinez, Saryu J. Fensin, Dan J. Thoma, Osman El‐Atwani   +11 more
wiley   +1 more source

DEFINING MOMENTS IN THE EMERGENCE AND EVOLUTION OF INTERNAL AUDIT IN OUR COUNTRY

Bulletin of "Carol I" National Defense University, 2021
The appearance and improvement of the internal audit activity in the public and private entities from Romania represented and constitutes a natural necessity, a consequence of the tendencies and practices manifested on international and European level ...
Vasile TIMOFTE
doaj  

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Peranan Internal Audit dalam International Standars Audit

Karimah Tauhid
Akselerasi digital serta munculnya risiko baru seperti siber, AI, dan tuntutan ESG pada periode 2020–2025 telah mengubah ekspektasi pemangku kepentingan terhadap fungsi auditor. Standar audit global, International Standards on Auditing (ISA), yang bertujuan meningkatkan kualitas audit, harus diimplementasikan dalam konteks risiko yang terus berkembang ...
Putri Permatasari, Siti Edeniah, Julia Fitria Rahman, null Didi   +3 more
openaire   +1 more source

Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays

Advanced Science, EarlyView.
An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen, Bin Li, Yingying Wang, Fulin Zhu, Wenxuan Yang, Xuanyu Fu, Tiantian Man, Qiuyue Wu, Kewei Ren, Shengyuan Deng   +9 more
wiley   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

CLASSIFICATION AND CHARACTERISTICS OF THE INTERNAL AUDIT PRINCIPLES

Финансы: теория и практика, 2017
The modern requirements to the risk-oriented internal audit necessitate establishment of an internal audit service integrated into the JSC corporate management structure.
A. V. Smetanko
doaj   +1 more source

Texas Lottery Commission Internal Audit: Retailer Accounts

, 2009
Report detailing the Internal Audit Division's review of Retailer Accounts, in order to evaluate the adequacy and effectiveness of internal controls for ensuring accurate and efficient retailer collections and adjustments, and to evaluate tools in place ...
Texas Lottery Commission. Internal Audit Division.
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