Results 51 to 60 of about 2,991,069 (277)
Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties
Advanced Science, EarlyView.Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen +16 morewiley +1 more sourceMeta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]
, 2011 Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.Taylor, K, Rice, K. (Kenneth), Petrovic, K. (Katja), Orru, M, Meisinger, C. (Christa), Fox, Caroline S., Ralph B D'Agostino, Ballantyne, C. (Christie), Rivadeneira Ramirez, F. (Fernando), Demissie, S, Sanna, Serena, Harris, Tamara B, Markus, Hugh S, Petrovic, KE, Huffman, J.E. (Jennifer), White, C.C. (Charles), Heiss, G. (Gerardo), Sanna, S, Eiriksdottir, Gudny, Newman, Anne B, Peltonen, L, Smith, AV, Huffman, JE, Couper, DJ, Huffman, Jennifer E., Blankenberg, Stefan, Baumert, J. (Jens), Lüdemann, Jan, Reinhold Schmidt, Arne Schillert, Sitzer, M, Dörr, M. (Marcus), Manuela Uda, Steve Bevan, Serkalem Demissie, Boerwinkle, Eric, Xia Li, O'Leary, Daniel H, Eiriksdottir, G, Ulf Schminke, O'Donnell, CJ, Wichmann, H.E. (Heinz Erich), Kavousi, M, Halperin, E, Boerwinkle, E, Illig, T. (Thomas), Heiss, G, Heckbert, Susan R, Bis, JC, Tamara B Harris, Harris, T.B. (Tamara), Smith, Albert V, Launer, Lenore J, Ziegler, A, Schmidt, Reinhold, Heckbert, Susan R., Meisinger, Christa, Wild, P.S. (Philipp), Polak, Joseph F., Klopp, Norman, Cupples, L.A. (Adrienne), Joseph F Polak, Aspelund, T. (Thor), Wolf, PA, Couper, David J., Alan R Shuldiner, White, Charles C, Rivadeneira, F, Homuth, G, Gonçalo R Abecasis, Cheng, YC, Maryam Kavousi, Taylor, Kent, White, CC, Li, X. (Xia), ?, ?, Orru, Marco, Wild, PS, Bevan, S, Duijn, Cornelia, Wendy S Post, Abbas Dehghan, Halperin, E. (Eran), Luedemann, Jan, Smith, A.V. (Albert Vernon), Münzel, T, Franceschini, N. (Nora), Kähönen, M, Stoegerer, EM, Baumert, Jens, Reilly, Muredach P., Thomas Illig, Völzke, H. (Henry), Homuth, G. (Georg), D'Agostino, RB, Lenore J Launer, Schminke, Ulf, Christie Ballantyne, Franceschini, N, Uda, Manuela, Wild, Philipp S, Scuteri, Angelo, Huffman, Jennifer E, Rice, Kenneth, Hugh S Markus, Christopher J O'Donnell, Launer, Lenore J., Usala, G, Fernando Rivadeneira, Jacqueline Witteman, Post, WS, Norman Klopp, Gudnason, V. (Vilmundur), Petrovic, Katja E., Mitchell, BD, Uitterlinden, Andre, Post, W.S. (Wendy S.), Wolf, Philip A, Reilly, M.P. (Muredach), Rotter, Jerome I, Franceschini, Nora, Newman, Anne B., Andreas Ziegler, Marco Orru, Uitterlinden, A, Fox, CS, Dörr, Marcus, Schnabel, R.B. (Renate), Edward G Lakatta, Nambi, Vijay, Isaacs, Aaron; id_orcid, Cheng, Yu-Ching, Uitterlinden, A.G. (André), Ben Oostra, Wilson, James F, Stefan Blankenberg, Schmidt, Helena, O'Donnell, C.J. (Christopher), Koenig, W, Völzke, H, Reilly, MP, Thomas Münzel, Mika Kähönen, Dehghan, Abbas, Gudnason, V, Bevan, Steve, Raitakari, O, Thorsson, Bolli, Yu-Ching Cheng, Isaacs, A.J. (Aaron), Caroline S Fox, Koenig, Wolfgang, Albert V Smith, Cupples, LA, Rathmann, W, Bruce M Psaty, Andre Uitterlinden, Zeller, T, Smith, Albert V., Shuldiner, Alan R, Florian Ernst, Ballantyne, C, Kavousi, M. (Maryam), Chilukoti, R.K. (Ravi Kumar), Ziegler, Andreas, Duijn, CV, Schillert, A, Lakatta, Edward G., Psaty, B.M. (Bruce), Homuth, Georg, Harris, TB, O'Leary, D.H. (Daniel H.), Ernst, Florian, Raitakari, Olli, Post, Wendy S, Shuldiner, AR, Demissie, S. (Serkalem), Abecasis, GR, Oostra, B.A. (Ben), Schnabel, RB, Joshua C Bis, Wilson, James F., Kathiresan, S. (Sekar), Gerardo Heiss, Thor Aspelund, Hofman, Albert, Eric Boerwinkle, Illig, Thomas, Mitchell, B.D. (Braxton), Schillert, Arne, Hayward, C, Voelzke, Henry, North, K, Polak, Joseph F, Polak, JF, Halperin, Eran, Lehtimäki, T. (Terho), Tanja Zeller, Lakatta, E. (Edward), Joachim Thiery, Helena Schmidt, David J Couper, Aaron Isaacs, Demissie, Serkalem, Rotter, JI, Seissler, J. (Jochen), Petrovic, Katja E, Chilukoti, Ravi Kumar, Duijn, C.M. (Cornelia) van, Thiery, Joachim, Thorsson, B. (Bolli), Schillert, A. (Arne), Psaty, Bruce M., Mitchell, Braxton D., Henry Völzke, Kenneth Rice, Lüdemann, J, Lehtimaki, Terho, Isaacs, A, Marcus Dörr, Matthias Sitzer, Witteman, Jacqueline, Uda, M. (Manuela), Bis, Joshua C, Lehtimäki, T, Shuldiner, A.R. (Alan), Bevan, S. (Steve), null null, Serena Sanna, H Erich Wichmann, Lakatta, EG, Abecasis, G.R. (Gonçalo), Parsa, Afshin, Bis, J.C. (Joshua), Uda, M, Wichmann, H Erich, Blankenberg, S. (Stefan), Shuldiner, Alan R., Anne B Newman, Hofman, Bert, North, Kari, Thiery, J.P. (Joachim), Dörr, M, Afshin Parsa, Vijay Nambi, Zeller, Tanja, Schminke, U. (Ulf), Chilukoti, RK, Leena Peltonen, Rotter, J.I. (Jerome), Psaty, Bruce M, Heckbert, SR, Dehghan, A, Nambi, V, Witteman, J, Polak, J.F. (Joseph F.), Jorma Viikari, Kari North, Eran Halperin, Daniel H O'Leary, Wolf, Philip A., Seissler, Jochen, Usala, G., O'Leary, DH, Heckbert, S.R. (Susan), Ballantyne, Christie, Nora Franceschini, North, K.E. (Kari), Jennifer E Huffman, Jan Lüdemann, Vilmundur Gudnason, Meisinger, C, Jens Baumert, Rivadeneira, Fernando, Ziegler, A. (Andreas), O'Donnell, Christopher J., Eiriksdottir, G. (Gudny), Kathiresan, S, Wolf, P.A. (Philip), Cheng, Y.C. (Yu Ching), van Duijn, Cornelia, Rathmann, Wolfgang, Wolfgang Koenig, Zeller, T. (Tanja), Peltonen, Leena, Kent Taylor, Kähönen, M. (Mika), D'Agostino, Ralph B, Olli Raitakari, Völzke, Henry, Ernst, F, Mitchell, Braxton D, Wichmann, HE, Heiss, Gerardo, Muenzel, Thomas, Abecasis, Goncalo R., Koenig, W. (Wolfgang), James F Wilson, Viikari, J. (Jorma), Wilson, James F; id_orcid, Boerwinkle, E.A. (Eric), Susan R Heckbert, Markus, HS, Seissler, J, Bis, Joshua C., O'Leary, Daniel H., Klopp, N, Ravi Kumar Chilukoti, Stoegerer, E.M. (Eva Maria), Usala, Gianluca, Fox, C.S. (Caroline), Caroline Hayward, Harris, Tamara B., Li, X, Parsa, A, Jochen Seissler, Abecasis, Gonçalo R, Illig, T, Jerome I Rotter, Cupples, L Adrienne, Cupples, L. Adrienne, Launer, LJ (Lenore), Gudnason, Vilmundur, Lakatta, Edward G, Schmidt, R, Scuteri, A, Bolli Thorsson, Stoegerer, Eva-Maria, Uitterlinden, André; id_orcid, Post, Wendy S., Schmidt, R. (Reinhold), Schmidt, H, Kahonen, Mika, Cornelia van Duijn, Angelo Scuteri, Philipp S Wild, Viikari, J, Schnabel, Renate B, Baumert, J, Peltonen, L. (Leena Johanna), Renate B Schnabel, Sekar Kathiresan, Muredach P Reilly, D'Agostino, Ralph Sr., Rice, K, Philip A Wolf, Parsa, A. (Afshin), Doerr, Marcus, Orrù, M. (Marco), White, Charles C., Dehghan, A. (Abbas), Hayward, Caroline, Hofman, A. (Albert), Münzel, Thomas, Witteman, JCM, Blankenberg, S, Albert Hofman, Schnabel, Renate B., O'Donnell, Christopher J, D'Agostino, Ralph B., Sr., Sitzer, Matthias, CARDIoGRAM Consortium, Katja E Petrovic, Viikari, Jorma, Oostra, B, Ernst, F.D.J. (Florian), Aspelund, T, Rathmann, W. (Wolfgang), D'Agostino, R.B. (Ralph), Couper, D.J. (David), Couper, David J, Thorsson, B, Psaty, BM, Wolfgang Rathmann, Hayward, C. (Caroline), Oostra, Ben, Aspelund, Thor, Reilly, Muredach P, Georg Homuth, Markus, H.S. (Hugh S.), Lüdemann, J. (Jan), Gianluca Usala, Taylor, K.D. (Kent), Isaacs, Aaron, Wichmann, H. Erich, Raitakari, O. (Olli), Hofman, A, Kathiresan, Sekar, Wilson, JF, Launer, L.J. (Lenore), Markus, Hugh S., Schminke, U, Charles C White, Launer, LJ, Thiery, J, Sanna, S. (Serena), Duijn, Cornelia van, Newman, AB, Newman, A.B. (Anne), Christa Meisinger, Witteman, J.C.M. (Jacqueline), Klopp, N. (Norman), Wild, Philipp S., Wilson, J.F. (James), Eva-Maria Stoegerer, Hayward, Caroline; id_orcid, Kavousi, Maryam, Nambi, V. (Vijay), Sitzer, M. (Matthias), Rotter, Jerome I., Münzel, T. (Thomas), Gudny Eiriksdottir, Braxton D Mitchell, L Adrienne Cupples, Terho Lehtimäki, Li, Xia, Scuteri, A. (Angelo), Fox, Caroline S +417 morecore +1 more sourceAstrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion
Advanced Science, EarlyView.ABSTRACT
Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen +7 morewiley +1 more sourceSevere ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT
Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem +12 morewiley +1 more sourceIntraplaque Hemorrhage in Chronic Anterior Circulation Arterial Occlusion: Associated Factors and Vessel‐Specific Patterns on High‐Resolution Magnetic Resonance Imaging
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Chronic anterior circulation arterial occlusion, particularly involving the internal carotid artery or middle cerebral artery (MCA), carries a persistent risk of ischemic events.Yaping Meng, Lingmin Zhao, Tao Chen, Shoufeng Liu, Shenna Niu, Chengcheng Cui, Yajing Wang, Wei Wang, Yilin Ma, Yue Zhang, Yuxin Xing, Kai Zheng, Ying Cai, Jieli Chen, Jialing Wu +14 moredoaj +1 more source
